DUSP4

  • Official Full Name

    dual specificity phosphatase 4

  • Overview

    The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK1, ERK2 and JNK, is expressed in a variety of tissues, and is localized in the nucleus. Two alternatively spliced transcript variants, encoding distinct isoforms, have been observed for this gene. In addition, multiple polyadenylation sites have been reported.

  • Synonyms

    DUSP4;dual specificity phosphatase 4;dual specificity protein phosphatase 4;HVH2;MAP kinase phosphatase 2;MKP 2;TYP;VH1 homologous phosphatase 2;dual specificity protein phosphatase hVH2;serine/threonine specific protein phosphatase;mitogen-acti

Recombinant Proteins

  • Human
  • Zebrafish
  • Rat
  • Mouse
  • Chicken
  • E.coli
  • Wheat Germ
  • Mammalian Cell
  • HEK293
  • HEK293T
  • Insects cell
  • In Vitro Cell Free System
  • His
  • GST
  • Non
  • Myc&DDK
  • His&Fc&Avi
Cat.# Product name Source (Host) Species Tag Protein Length Price
DUSP4-2645H Recombinant Human DUSP4 protein, His-tagged E.coli Human His 80-181 aa
DUSP4-101H Recombinant Human DUSP4, GST-tagged Wheat Germ Human GST
DUSP4-11388Z Recombinant Zebrafish DUSP4 Mammalian Cell Zebrafish His
DUSP4-1976R Recombinant Rat DUSP4 Protein Mammalian Cell Rat His
DUSP4-4890M Recombinant Mouse DUSP4 Protein Mammalian Cell Mouse His
DUSP4-6401C Recombinant Chicken DUSP4 Mammalian Cell Chicken His
DUSP4-6773HCL Recombinant Human DUSP4 293 Cell Lysate HEK293 Human Non
DUSP4-6774HCL Recombinant Human DUSP4 293 Cell Lysate HEK293 Human Non
DUSP4-1041H Recombinant Human DUSP4 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Human Myc&DDK
DUSP4-105H Recombinant Human DUSP4 Protein, Myc/DDK-tagged HEK293T Human Myc&DDK
DUSP4-106H Active Recombinant Human DUSP4 Protein, His-tagged Insects cell Human His
DUSP4-138HF Recombinant Full Length Human DUSP4 Protein, GST-tagged In Vitro Cell Free System Human GST Full L. 1 a.a. - 394 a.a.
DUSP4-1635R Recombinant Rat DUSP4 Protein, His (Fc)-Avi-tagged HEK293 Rat His&Fc&Avi
DUSP4-1635R-B Recombinant Rat DUSP4 Protein Pre-coupled Magnetic Beads HEK293 Rat
DUSP4-2572M Recombinant Mouse DUSP4 Protein, His (Fc)-Avi-tagged HEK293 Mouse His&Fc&Avi
DUSP4-2572M-B Recombinant Mouse DUSP4 Protein Pre-coupled Magnetic Beads HEK293 Mouse
Dusp4-2690M Recombinant Mouse Dusp4 Protein, Myc/DDK-tagged HEK293T Mouse Myc&DDK
DUSP4-2919H Recombinant Human DUSP4 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Human Myc&DDK

    Involved Pathway

    DUSP4 involved in several pathways and played different roles in them. We selected most pathways DUSP4 participated on our site, such as ARMS-mediated activation,Activated TLR4 signalling,Axon guidance, which may be useful for your reference. Also, other proteins which involved in the same pathway with DUSP4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Developmental Biology TCF4,TCF12,RHOAE,DUSP2,DCC,DNM1,HIF3A,CSNK2A2,WDR83,DPYSL5B
    Cytokine Signaling in Immune system TRIM68,UBE2V1,MX2,DUSP7,WDR83,TRIM3,IFIT8,EIF4G2A,CSHL1,IFIT3
    ARMS-mediated activation NRG2A,DUSP6,SLC14A2,FRS3,IL17RD,KLB,PSMD5,PSMD10,DUSP7,CSK
    DAP12 signaling MARK3,SPNA1,DUSP6,LAMTOR2,SPTBN1,SPRED1,PAQR3A,TRAT1,AGO2,DUSP7
    Axon guidance DAB2IPB,EZRA,AP2A1,SEMA6A,SEMA4D,Ntng2,KIF4,NCK2,DPYSL2B,NTN4
    B Cell Receptor Signaling Pathway HRAS,PPP3R1,DOK1B,MALT1,SOS1,AKT2,KRAS,MAP2K1,IGHM,NFKB1
    DAP12 interactions FGF20A,CLEC5A,CSF2RB,DUSP2,DUSP5,PRKAR1AA,HBEGF,PHB,CNKSR1,NRG3
    Activated TLR4 signalling CREB1B,SIGIRR,PELI2,DUSP3B,S100A12,TIRAP,RIPK3,PELI3,UBE2V1,APPA

    Protein Function

    DUSP4 has several biochemical functions, for example, MAP kinase tyrosine/serine/threonine phosphatase activity,protein tyrosine phosphatase activity,protein tyrosine/serine/threonine phosphatase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by DUSP4 itself. We selected most functions DUSP4 had, and list some proteins which have the same functions with DUSP4. You can find most of the proteins on our site.

    Function Related Protein
    protein tyrosine phosphatase activity EPM2A,PTPRFB,PTPN1,MTMR7,PTPN20B,PTPN14,DUSP15,PTP4A2B,PTPN2B,DUSP7
    MAP kinase tyrosine/serine/threonine phosphatase activity DUSP1,DUSP9,PTPRQ,SACM1L,DUSP7,SACM1LB,DUSP14,SACM1LA,DUSP10,NT5DC3
    protein tyrosine/serine/threonine phosphatase activity DUSP14,SSH2B,TPTE,CDC14AB,DUSP2,EPM2A,PTP4A2B,DUSP23A,DUSP21,CDKN3
    protein tyrosine/threonine phosphatase activity DUSP19,PXYLP1,PTPRQ,NT5DC3,DUSP2,SACM1LA,CTDSPL2B,DUSP1,CTDSPL2A,SACM1L

    Interacting Protein

    DUSP4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DUSP4 here. Most of them are supplied by our site. Hope this information will be useful for your research of DUSP4.

    MAPK1;MAPK9;MAPK8;MAPK14;CRMP1;MAPK1

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