DUSP2

  • Official Full Name

    dual specificity phosphatase 2

  • Overview

    The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily.These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues.They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation.Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli.This gene product inactivates ERK1 and ERK2, is predominantly expressed in hematopoietic tissues, and is localized in the nucleus.

  • Synonyms

    DUSP2;dual specificity phosphatase 2;dual specificity protein phosphatase 2;PAC 1;Dual specificity protein phosphatase PAC 1;DUSP 2;PAC1;Serine/threonine specific protein phosphatase;OTTHUMP00000161013;dual-specificity phosphatase 2;dual specificity protein phosphatase PAC-1;PAC-1

Recombinant Proteins

  • Human
  • Mouse
  • Zebrafish
  • Wheat Germ
  • E.coli
  • Mammalian Cell
  • In Vitro Cell Free System
  • HEK293
  • GST
  • His
  • His&Fc&Avi
Cat.# Product name Source (Host) Species Tag Protein Length Price
DUSP2-101H Recombinant Human DUSP2, GST-tagged Wheat Germ Human GST
DUSP2-45H Recombinant Human DUSP2 protein, His-tagged E.coli Human His 185aa(including fusion tag)
DUSP2-4883M Recombinant Mouse DUSP2 Protein Mammalian Cell Mouse His
DUSP2-898Z Recombinant Zebrafish DUSP2 Mammalian Cell Zebrafish His
DUSP2-132HF Recombinant Full Length Human DUSP2 Protein, GST-tagged In Vitro Cell Free System Human GST Full L. 1 a.a. - 314 a.a.
DUSP2-2566M Recombinant Mouse DUSP2 Protein, His (Fc)-Avi-tagged HEK293 Mouse His&Fc&Avi
DUSP2-2566M-B Recombinant Mouse DUSP2 Protein Pre-coupled Magnetic Beads HEK293 Mouse

    Involved Pathway

    DUSP2 involved in several pathways and played different roles in them. We selected most pathways DUSP2 participated on our site, such as ARMS-mediated activation,Axon guidance,Cytokine Signaling in Immune system, which may be useful for your reference. Also, other proteins which involved in the same pathway with DUSP2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Cytokine Signaling in Immune system EIF4A1,TRIM5,ADAR,EIF4EB,TRIM38,CSF2,IRF4,JAK3,TRIM3,PHB
    Downstream signal transduction FGF10B,SPRED1,SPTBN1,DUSP7,DUSP10,PTPRA,LAMTOR2,AGO3,JAK1,RASGRP4
    ARMS-mediated activation DAB2IPB,JAK2,JAK3,FGF10B,PAQR3A,SPTBN2,PSME3,CSF2,FGF18B,PEBP1
    Axon guidance GSK3B,ARPC3,SEMA3AA,PTK2,RAC3,GNAI2,EFNB1,CSF2RA,KALRNB,RAC2
    Developmental Biology ACTR2B,EGR2,DUSP1,KCNQ2,CAP1,LEFTY1,ARPC1B,PEBP1,LGI1B,SCN8A
    DAP12 signaling CNKSR1,KLB,SPRED1,AGO2,DUSP10,PTPRA,MOV10,NRG3,RASGRP4,FGF8B
    DAP12 interactions WDR83,SPTB,KIR2DS2,AGO1,TREM1,DUSP1,FRS3,JAK3,PAQR3B,DUSP6
    Downstream signaling of activated FGFR1 IL17RD,PEA15,KBTBD7,SPTB,AGO2,PTPRA,MARK3,RASGEF1A,SPTA1,CNKSR1

    Protein Function

    DUSP2 has several biochemical functions, for example, MAP kinase tyrosine/serine/threonine phosphatase activity,mitogen-activated protein kinase binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by DUSP2 itself. We selected most functions DUSP2 had, and list some proteins which have the same functions with DUSP2. You can find most of the proteins on our site.

    Function Related Protein
    protein tyrosine phosphatase activity LRP8,PTPRM,MTMR1A,MDP1,DUSP16,EYA4,EYA1,PTPN23,PTPRUB,PTPRC
    protein tyrosine/threonine phosphatase activity CTDSPL2B,TENC1,NT5DC3,PXYLP1,PTPRQ,SACM1L,SACM1LB,DUSP19,DUSP4,CTDSPL2A
    MAP kinase tyrosine/serine/threonine phosphatase activity TENC1,DUSP7,DUSP6,PTPRQ,DUSP18,DUSP14,DUSP4,DUSP5,DUSP16,DUSP1
    mitogen-activated protein kinase binding MAPKAPK2A,EP300,NBR1,PLCB4,MAPKAPK5,MAPKAPK2B,ABL1,MAPK7,CDK5RAP3,ATF7
    protein binding RNPS1,MAGEA2B,EMID2,Trl,ILVBL,SORBS3,IGF1,SUPT4H1,DHX15,NDUFB11
    protein tyrosine/serine/threonine phosphatase activity SACM1LB,RNGTT,EYA3,DUSP19B,DUSP5,PTPDC1,DUSP22A,SACM1L,DUSP4,PTP4A2A

    Interacting Protein

    DUSP2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DUSP2 here. Most of them are supplied by our site. Hope this information will be useful for your research of DUSP2.

    MAPK3;MAPK1

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