DUSP11
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Official Full Name
dual specificity phosphatase 11 (RNA/RNP complex 1-interacting) -
Overview
The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product is localized to the nucleus and binds directly to RNA and splicing factors, and thus it is suggested to participate in nuclear mRNA metabolism. -
Synonyms
DUSP11;dual specificity phosphatase 11 (RNA/RNP complex 1-interacting);RNA/RNP complex-1-interacting phosphatase;PIR1;Dual specificity protein phosphatase 11;Phosphatase that interacts with RNA/RNP complex 1;RNA/RNP complex interacting phosphatase;RNA/RNP complex1 intereracting phosphatase;Serine/threonine specific protein phosphatase;RNA/RNP complex-interacting phosphatase
Recombinant Proteins
- Human
- Rat
- Zebrafish
- Mouse
- E.coli
- Mammalian Cell
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- GST
- His
- Non
- His&Fc&Avi
Involved Pathway
DUSP11 involved in several pathways and played different roles in them. We selected most pathways DUSP11 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with DUSP11 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
DUSP11 has several biochemical functions, for example, RNA binding,nucleotide phosphatase activity, acting on free nucleotides,phosphatase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by DUSP11 itself. We selected most functions DUSP11 had, and list some proteins which have the same functions with DUSP11. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein tyrosine/serine/threonine phosphatase activity | DUSP19B,SSH2,CDKN3,SACM1LB,CDC14AA,DUSP13A,SSH1,DUSP14,DUSP23,DUSP2 |
| poly(A) RNA binding | NUSAP1,FLYWCH2,RPL26,PTBP1,KIAA1324,RBM38,RPS19BP1,PELP1,UTP23,TRUB2 |
| protein tyrosine phosphatase activity | PTPRF,PTPRUB,DUSP23,DUSP18,MTMR14,DUSP9,SSH2,MTMR3,DUSP7,PTPRZ1 |
| phosphatase activity | PTPRK,PTPN11B,SACM1LB,MTMR1A,CTDNEP1,ALP3,MTMR7B,DUSP22B,CDC14AB,PTPRZ1 |
| nucleotide phosphatase activity, acting on free nucleotides | NUDT16,NTPCR,PGP |
| RNA binding | RNASEH1,EIF2S1A,NHP2L1B,NPM1,LRPPRC,TNRC6B,CSTF3,PPP5C,BARHL1,PTBP1A |
| polynucleotide 5-phosphatase activity | RNGTT |
Interacting Protein
DUSP11 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DUSP11 here. Most of them are supplied by our site. Hope this information will be useful for your research of DUSP11.
QARS;HNRNPA1;KIF11;Csde1;THOC1
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References
- Abers, HMHG; Kuijl, C; et al. Integrating Chemical and Genetic Silencing Strategies To Identify Host Kinase-Phosphatase Inhibitor Networks That Control Bacterial Infection. ACS CHEMICAL BIOLOGY 9:414-422(2014).
- Nallaparaju, KC; Zhang, YL; et al. DUSP11 is a critical regulator of innate immune responses mediated by dendritic cells. CYTOKINE 63:286-286(2013).
