DUOX1
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Official Full Name
dual oxidase 1 -
Overview
The protein encoded by this gene is a glycoprotein and a member of the NADPH oxidase family. The synthesis of thyroid hormone is catalyzed by a protein complex located at the apical membrane of thyroid follicular cells. This complex contains an iodide transporter, thyroperoxidase, and a peroxide generating system that includes this encoded protein and DUOX2. This protein is known as dual oxidase because it has both a peroxidase homology domain and a gp91phox domain. Two alternatively spliced transcript variants encoding the same protein have been described for this gene. -
Synonyms
DUOX1;dual oxidase 1;flavoprotein NADPH oxidase;LNOX1;NADPH thyroid oxidase 1;nicotinamide adenine dinucleotide phosphate oxidase;NOXEF1;THOX1;Dual oxidase 1 precursor;EC 1.11.1;EC 1.6.3.1;Large NOX 1;Long NOX 1;MGC138840;MGC138841;Thyroid oxidase 1
Recombinant Proteins
- Rat
- Human
- Mouse
- Mammalian Cell
- Wheat Germ
- HEK293
- HEK293T
- In Vitro Cell Free System
- His
- GST
- His&Fc&Avi
- Myc&DDK
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| DUOX1-1968R | Recombinant Rat DUOX1 Protein | Mammalian Cell | Rat | His |
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| DUOX1-2915H | Recombinant Human DUOX1 Protein, GST-tagged | Wheat Germ | Human | GST |
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| DUOX1-1627R | Recombinant Rat DUOX1 Protein, His (Fc)-Avi-tagged | HEK293 | Rat | His&Fc&Avi |
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| DUOX1-1627R-B | Recombinant Rat DUOX1 Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
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| Duox1-2676M | Recombinant Mouse Duox1 Protein, Myc/DDK-tagged | HEK293T | Mouse | Myc&DDK |
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| DUOX1-2713H | Recombinant Human DUOX1 Protein, MYC/DDK-tagged | HEK293 | Human | Myc&DDK |
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| DUOX1-4083HF | Recombinant Full Length Human DUOX1 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 941-1028 amino acids |
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Involved Pathway
DUOX1 involved in several pathways and played different roles in them. We selected most pathways DUOX1 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with DUOX1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
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Protein Function
DUOX1 has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by DUOX1 itself. We selected most functions DUOX1 had, and list some proteins which have the same functions with DUOX1. You can find most of the proteins on our site.
| Function | Related Protein |
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Interacting Protein
DUOX1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DUOX1 here. Most of them are supplied by our site. Hope this information will be useful for your research of DUOX1.
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References
- Xu, ZF; Luo, JT; et al. The BLI-3/TSP-15/DOXA-1 Dual Oxidase Complex Is Required for Iodide Toxicity in Caenorhabditis elegans. G3-GENES GENOMES GENETICS 5:195-203(2015).
- de Oliveira, S; Boudinot, P; et al. Duox1-Derived H2O2 Modulates Cxcl8 Expression and Neutrophil Recruitment via JNK/c-JUN/AP-1 Signaling and Chromatin Modifications. JOURNAL OF IMMUNOLOGY 194:1523-1533(2015).
