DTX3L
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Official Full Name
deltex 3-like -
Overview
DTX3L functions as an E3 ubiquitin ligase (Takeyama et al., 2003 (PubMed 12670957)). -
Synonyms
DTX3L;deltex 3-like (Drosophila);E3 ubiquitin-protein ligase DTX3L;BBAP;rhysin 2;rhysin2;rhysin-2;B-lymphoma- and BAL-associated protein
Recombinant Proteins
- Human
- Mouse
- E.coli
- Wheat Germ
- Mammalian Cell
- HEK293
- Mammalian cells
- HEK293T
- In Vitro Cell Free System
- GST
- His
- Non
- Flag
- His&Fc&Avi
- Myc&DDK
Involved Pathway
DTX3L involved in several pathways and played different roles in them. We selected most pathways DTX3L participated on our site, such as Adaptive Immune System,Antigen processing: Ubiquitination &,Proteasome degradation, which may be useful for your reference. Also, other proteins which involved in the same pathway with DTX3L were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Adaptive Immune System | AKR1C1,FGF10B,TREML2,ARF1,CREB1B,AP1B1,ASB9,MKRN1,TRIM69,RNF182 |
| Immune System | HBL3,EDA,DEFB1,KLRB1A,SRMS,ASB7,BLMH,TRIM56,BTR30,POLR3F |
| Antigen processing: Ubiquitination & | SH3RF1,FBXO3,RNF4,RNF144B,ASB6,LRRC41,RNF111,LRSAM1,UBE2U,RNF14 |
| Proteasome degradation | DZIP3,ASB17,WSB1,ASB9,UBA5,GAN,UBE2F,ATG7,UBE2V2,FBXO27 |
| Class I MHC mediated antigen processing & | RNF14,ASB11,UBR2,CYBB,LRR1,B2ML,MKRN1,FBXO3,RNF4,SEC24A |
| Notch signaling pathway | DLK1,CIR1,DTX2,KAT2A,DTX1,EP300,JAG1B,HER9,NCSTN,MAML2 |
| presentation | SH3RF1,TRIM9,TPP2,B2ML,TRIM63,GAN,ASB9,WSB1,FBXO44,RNF19B |
Protein Function
DTX3L has several biochemical functions, for example, histone binding,ligase activity,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by DTX3L itself. We selected most functions DTX3L had, and list some proteins which have the same functions with DTX3L. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| histone binding | HIST2H4,NAP1L2,TONSL,BRD7,ATRX,RNF168,HIST1H3C,CHD2,HIST2H4A,BRD1 |
| zinc ion binding | RNF182,NAPEPLD,TRAF4A,SH3RF3,TRAF2,CPA2,ADAM19,ADAMTS7,PDLIM7,BRPF3 |
| ubiquitin-protein transferase activity | HERC2,CNOT4B,BTR22,LNX1,LRSAM1,RNF13,ANAPC4,BIRC2,UBE2E2,SIAH1 |
| ligase activity | RNF20,TTLL13,TRAF7,CBL,MSL2,BIRC3,RFWD2,UBR1,MARCH9,RNF34 |
| protein binding | NUAK1,HOPX,ARHGEF4,TMIGD2,NPDC1,PDCL,FIP1L1,ITGA6,ACPL2,RBM12B |
Interacting Protein
DTX3L has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DTX3L here. Most of them are supplied by our site. Hope this information will be useful for your research of DTX3L.
SPG21;HIP2;UBE2D1;UBE2E1;UBE2D3;UBE2H;UBE2D2;UBE2I;RNF111;UBE2R2;UBE2E3;UBE2W;UBE2E2;PHF7;TRIM9;UBE2D4;MCM7
Resources
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References
- Holleman, J; Marchese, A; et al. The ubiquitin ligase deltex-3l regulates endosomal sorting of the G protein-coupled receptor CXCR4. MOLECULAR BIOLOGY OF THE CELL 25:1892-1904(2014).
- Bachmann, SB; Frommel, SC; et al. DTX3L and ARTD9 inhibit IRF1 expression and mediate in cooperation with ARTD8 survival and proliferation of metastatic prostate cancer cells. MOLECULAR CANCER 13:-(2014).
