DTX1
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Official Full Name
deltex homolog 1 (Drosophila) -
Overview
Studies in Drosophila have identified this gene as encoding a positive regulator of the Notch-signaling pathway. The human gene encodes a protein of unknown function; however, it may play a role in basic helix-loop-helix transcription factor activity. -
Synonyms
DTX1;deltex homolog 1 (Drosophila);protein deltex-1;hDx 1;Deltex protein 1;Deltex-1;Deltex1;FXI-T1;Fxit 1;Fxit1;mDTX1;hDTX1;OTTHUMP00000241684;hDx-1
Recombinant Proteins
- Human
- Mouse
- Zebrafish
- Wheat Germ
- Mammalian Cell
- E.coli
- HEK293
- In Vitro Cell Free System
- GST
- His
- His&T7
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| DTX1-2905H | Recombinant Human DTX1 Protein, GST-tagged | Wheat Germ | Human | GST |
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| DTX1-4856M | Recombinant Mouse DTX1 Protein | Mammalian Cell | Mouse | His |
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| DTX1-6779Z | Recombinant Zebrafish DTX1 | Mammalian Cell | Zebrafish | His |
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| DTX1-1842H | Recombinant Human DTX1 protein, His & T7-tagged | E.coli | Human | His&T7 | Gly290~His535 |
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| DTX1-2548M | Recombinant Mouse DTX1 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| DTX1-2548M-B | Recombinant Mouse DTX1 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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| DTX1-4067HF | Recombinant Full Length Human DTX1 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 620 amino acids |
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Involved Pathway
DTX1 involved in several pathways and played different roles in them. We selected most pathways DTX1 participated on our site, such as Notch signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with DTX1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Notch signaling pathway | DVL3A,DTX2,YY1,PSEN1,JAG1A,DLL3,NOTCH4,DLK1,NUMBL,RBPJ |
Protein Function
DTX1 has several biochemical functions, for example, Notch binding,SH3 domain binding,UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by DTX1 itself. We selected most functions DTX1 had, and list some proteins which have the same functions with DTX1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| tubulin-glutamic acid ligase activity | HECW2,MUL1A,UBE2IA,MYLIPB,MARCH9,SIAH2L,RNF169,SHRPRBCK1R,ARIH1L,NEURL1B |
| ligase activity | TRAF6,GLULC,RCHY1,MIB1,PIAS2,PELI2,TTLL5,UBE2IA,HERC4,RBCK1 |
| protein-glutamic acid ligase activity | MARCH9,ITCHA,ARIH1L,RC3H2,RNF144AA,RNF144AB,TRIM50,MARCH6,SHRPRBCK1R,RNF149 |
| tubulin-glycine ligase activity | G2E3,MYLIPB,MARCH5L,RAG1,TRIM50,RNF144AB,FLR,NEURL3,MARCH9,RNF169 |
| SH3 domain binding | DNM2,SH3BGR,QKIA,SGIP1,PDE4D,DRD4,BCAR1,CNTNAP1,DENND1A,OSTF1 |
| protein-glycine ligase activity, initiating | TRIM50,RC3H2,MARCH6,G2E3,ARIH1L,MARCH5L,RNF187,ITCHA,NEURL3,RNF169 |
| ubiquitin protein ligase binding | WFS1,SMAD5,PACRG,ATP6V0C,POLR2A,UBE2H,TRAF3,SMC6,TP53,PRKAR2A |
| zinc ion binding | MAN2B2,ZNFL1,DPF2,FANCL,ADAM7,ZFAND2A,RBM14A,PCGF5,TRIM35-29,RBCK1 |
| metal ion binding | CSGALNACT1,EXTL3,ZSCAN4D,ZFP41,ATMIN,ZSCAN4C,SMAD1,ATP5S,AMY1B,ATP11A |
Interacting Protein
DTX1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DTX1 here. Most of them are supplied by our site. Hope this information will be useful for your research of DTX1.
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References
- Aste-Amezaga, M; Zhang, NY; et al. Characterization of Notch1 Antibodies That Inhibit Signaling of Both Normal and Mutated Notch1 Receptors. PLOS ONE 5:-(2010).
- Laycock, MV; Jellett, JF; et al. First report of a new rapid assay for diarrhetic shellfish poisoning toxins. HARMFUL ALGAE 5:74-78(2006).
