DTL
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Official Full Name
denticleless homolog (Drosophila) -
Overview
Denticleless protein homolog is a protein that in humans is encoded by the DTL gene. -
Synonyms
DTL;denticleless homolog (Drosophila);denticleless protein homolog;DCAF2;DDB1 and CUL4 associated factor 2;L2DTL;RA regulated nuclear matrix associated protein;RAMP;Lethal(2) denticleless protein homolog;CDW1;Ddb1- and Cul4-associated factor 2;Denticleless homolog;DTL_HUMAN;Retinoic acid regulated nuclear matrix associated protein;Retinoic acid-regulated nuclear matrix-associated protein;RA-regulated nuclear matrix-associated protein;CDT2
Recombinant Proteins
- Human
- Rhesus macaque
- Chicken
- Mouse
- Zebrafish
- E.coli
- Mammalian Cell
- HEK293
- Mammalian cells
- HEK293T
- His
- His&GST
- Non
- His&Fc&Avi
- Flag
- Myc&DDK
Involved Pathway
DTL involved in several pathways and played different roles in them. We selected most pathways DTL participated on our site, such as DNA Damage Bypass,DNA Repair,Recognition of DNA damage by PCNA-containing replication complex, which may be useful for your reference. Also, other proteins which involved in the same pathway with DTL were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| DNA Damage Bypass | POLD3,POLI,USP10,MAD2L2,USP43A,USP43,SPRTN,KIAA0101,RAD18,DDB1 |
| DNA Repair | NFRKB,RAD9A,PPP4R2,ZBTB32,RTEL1,RAD17,TIMELESS,ACTL6A,CETN2,RNF4 |
| Recognition of DNA damage by PCNA-containing replication complex | ZBTB32,RAD18 |
Protein Function
DTL has several biochemical functions, for example, protein binding,contributes_to ubiquitin-protein transferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by DTL itself. We selected most functions DTL had, and list some proteins which have the same functions with DTL. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| contributes_to ubiquitin-protein transferase activity | UBE2C,KLHDC8A,KBTBD10,BTRC,KLHL3,KBTBD6,BACH1A,KLHL38,PHOSPHO2-KLHL23,IPP |
| protein binding | EXOC1,RPLP2,DRD1,RNF213,CUBN,COPS3,CYBA,ARHGEF16,USP12,SPINK2 |
Interacting Protein
DTL has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DTL here. Most of them are supplied by our site. Hope this information will be useful for your research of DTL.
DDB1;WDR5;Dtl;Ddb1;COPS6;CUL4A;CUL4B;GRWD1
Resources
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References
- Urity, VB; Issaian, T; et al. Architecture of kangaroo rat inner medulla: segmentation of descending thin limb of Henle's loop. AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY 302:R720-R726(2012).
- Dantzler, WH; Pannabecker, TL; et al. Urine concentrating mechanism in the inner medulla of the mammalian kidney: role of three-dimensional architecture. ACTA PHYSIOLOGICA 202:361-378(2011).
