DROSHA
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Official Full Name
drosha, ribonuclease type III -
Overview
Members of the ribonuclease III superfamily of double-stranded (ds) RNA-specific endoribonucleases participate in diverse RNA maturation and decay pathways in eukaryotic and prokaryotic cells (Fortin et al., 2002 [PubMed 12191433]). The RNase III Drosha is the core nuclease that executes the initiation step of microRNA (miRNA) processing in the nucleus (Lee et al., 2003 [PubMed 14508493]).[supplied by OMIM, Mar 2008] -
Synonyms
DROSHA;drosha, ribonuclease type III;RN3;ETOHI2;RNASEN;RANSE3L;RNASE3L;HSA242976;ribonuclease 3;p241;RNase III;protein Drosha;nuclear RNase III Drosha;putative ribonuclease III;ribonuclease III, nuclear;ribonuclease type III, nuclear;drosha, double-stranded RNA-specific endoribonuclease;putative protein p241 which interacts with transcription factor Sp1
Recombinant Proteins
- Human
- Rhesus macaque
- Chicken
- Mouse
- E.coli
- Mammalian Cell
- HEK293
- Mammalian cells
- GST
- His
- His&Fc&Avi
- Myc&DDK
Involved Pathway
DROSHA involved in several pathways and played different roles in them. We selected most pathways DROSHA participated on our site, such as Ribosome biogenesis in eukaryotes,Proteoglycans in cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with DROSHA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Ribosome biogenesis in eukaryotes | RCL1,NXT2,NXF1,GNL3,SBDS,RNASEN,RPP40,GAR1,UTP18,NHP2L1B |
| Proteoglycans in cancer | MMP2,MET,PIK3R2,HPSE,TGFB1,RPS6KB1,THBS1,RPS6KB2,COL21A1,MAPK11 |
Protein Function
DROSHA has several biochemical functions, for example, RNA binding,double-stranded RNA binding,endonuclease activity. Some of the functions are cooperated with other proteins, some of the functions could acted by DROSHA itself. We selected most functions DROSHA had, and list some proteins which have the same functions with DROSHA. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| nuclease activity | HARBI1,DNASE1L3L,EXOSC9,ASTE1,TMPPE,SND1,REXO4,RNASEKA,EXO5,USB1 |
| endoribonuclease activity | ERN1,RNASEKA,CPSF3,TSNAX,RNASEL,ENDOU2,AGO2,RCL1,RNASET2,PLD6 |
| protein homodimerization activity | PVALB,GDF6,DHDPSL,HMOX1,LDB1,USF1,SLC22A6,VPS24,CIB2,HEXB |
| RNA binding | DUSP11,HNRNPH3,RPL39L,KHDC1C,RBMS1,IREB2,SRSF1,SUZ12,DDX51,EIF3K |
| double-stranded RNA binding | TARBP2,OASL,OASL2,HSP90AB1,DDX21,MTDH,STAU2,ZNF346,DHX15,MBNL1 |
| ribonuclease III activity | DICER1,RNASEN,BARHL1,AGFG1A,MRPL44 |
| lipopolysaccharide binding | BPIFA2,LBP,BPIFC,TLR4,HSPD1,HMGB1,PTAFR,CD14,PSMB4,P2RX7 |
| endonuclease activity | ERN2,SMG6,EAR3,DNASE1L3L,RNASE4,RNASEL4,MRE11A,RNASE2,ENDOG,ZRANB3 |
| protein binding | C11orf57,EIF5B,RTN4RL1B,TERF2IP,CLPB,CCNG1,ABCG1,MAGI2,SRI,DAPP1 |
Interacting Protein
DROSHA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DROSHA here. Most of them are supplied by our site. Hope this information will be useful for your research of DROSHA.
Ddx17
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References
- Alarcon, CR; Lee, H; et al. N-6-methyladenosine marks primary microRNAs for processing. NATURE 519:482-+(2015).
- Walz, AL; Ooms, A; et al. Recurrent DGCR8, DROSHA, and SIX Homeodomain Mutations in Favorable Histology Wilms Tumors (vol 27, pg 286, 2015). CANCER CELL 27:426-426(2015).
