DRAM1
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Official Full Name
DNA-damage regulated autophagy modulator 1 -
Overview
This gene is regulated as part of the p53 tumor suppressor pathway. The gene encodes a lysosomal membrane protein that is required for the induction of autophagy by the pathway. Decreased transcriptional expression of this gene is associated with various tumors. This gene has a pseudogene on chromosome 4. -
Synonyms
DRAM1;DNA-damage regulated autophagy modulator 1;DNA damage-regulated autophagy modulator protein 1;damage regulated autophagy modulator;DRAM;FLJ11259;damage-regulated autophagy modulator
Recombinant Proteins
- Rhesus macaque
- Zebrafish
- Mouse
- Human
- Mus musculus
- Xenopus laevis
- Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
- Mammalian Cell
- HEK293
- E.coli expression system
- His
- Non
- His&Fc&Avi
Involved Pathway
DRAM1 involved in several pathways and played different roles in them. We selected most pathways DRAM1 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with DRAM1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
DRAM1 has several biochemical functions, for example, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by DRAM1 itself. We selected most functions DRAM1 had, and list some proteins which have the same functions with DRAM1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | SH2D3A,PASK,POU4F1,PIM1,RBL1,RAD51L3,SFTPC,SLC9A1,STX8,HCFC1 |
Interacting Protein
DRAM1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DRAM1 here. Most of them are supplied by our site. Hope this information will be useful for your research of DRAM1.
C1orf21
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References
- Guan, JJ; Zhang, XD; et al. DRAM1 regulates apoptosis through increasing protein levels and lysosomal localization of BAX. CELL DEATH & DISEASE 6:-(2015).
- Yu, MQ; Jiang, YG; et al. DRAM1 Protects Neuroblastoma Cells from Oxygen-Glucose Deprivation/Reperfusion-Induced Injury via Autophagy. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 15:19253-19264(2014).
