DPYSL5
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Official Full Name
dihydropyrimidinase-like 5 -
Overview
This gene encodes a member of the CRMP (collapsing response mediator protein) family thought to be involved in neural development. Antibodies to the encoded protein were found in some patients with neurologic symptoms who had paraneoplastic syndrome. A pseudogene of this gene is found on chromosome 11. Multiple alternatively spliced variants, encoding the same protein, have been identified. -
Synonyms
DPYSL5;dihydropyrimidinase-like 5;dihydropyrimidinase-related protein 5;CRAM;CRMP 5;CRMP5;Ulip6;DRP-5;ULIP-6;CRMP3-associated molecule;UNC33-like phosphoprotein 6;collapsin response mediator protein 5;collapsin response mediator protein-5;CRMP-5;FLJ45383
Recombinant Proteins
- Human
- Rat
- Mouse
- E.coli
- Mammalian Cell
- Wheat Germ
- HEK293
- HEK293T
- Mammalian cells
- In Vitro Cell Free System
- GST
- His
- Non
- His&Fc&Avi
- Myc&DDK
- Flag
- His&Myc
Involved Pathway
DPYSL5 involved in several pathways and played different roles in them. We selected most pathways DPYSL5 participated on our site, such as Axon guidance, which may be useful for your reference. Also, other proteins which involved in the same pathway with DPYSL5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Axon guidance | UNC5D,LIMK1,EPHA4A,FRS2,DUSP10,CNTN1,EPHA8,FES,TRPC4,DAB2IPB |
Protein Function
DPYSL5 has several biochemical functions, for example, hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds,microtubule binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by DPYSL5 itself. We selected most functions DPYSL5 had, and list some proteins which have the same functions with DPYSL5. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds | DPYSL4,NAAA,YDJC,DPYSL2B,DPYSL3,CRMP1,DPYSL5A,BTD,DPYSL5B |
| microtubule binding | GAS2L3,GOLGA2,REEP4,BIRC5,LRPPRC,KIF11,KIF3C,CETN1,TXNDC3,DCX |
| protein binding | ZNF599,PPP5C,FBXO9,RNF43,NXF1,RTN4R,DYRK1B,PEX11B,FGF12,TRIM39 |
Interacting Protein
DPYSL5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DPYSL5 here. Most of them are supplied by our site. Hope this information will be useful for your research of DPYSL5.
DPYSL2;HSPA5;DARS2;APPL1
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References
- Akane, H; Shiraki, A; et al. Glycidol induces axonopathy and aberrations of hippocampal neurogenesis affecting late-stage differentiation by exposure to rats in a framework of 28-day toxicity study. TOXICOLOGY LETTERS 224:424-432(2014).
- Manivannan, J; Tay, SSW; et al. DIHYDROPYRIMIDINASE-LIKE 3 REGULATES THE INFLAMMATORY RESPONSE OF ACTIVATED MICROGLIA. NEUROSCIENCE 253:40-54(2013).
