DPM1
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Official Full Name
dolichyl-phosphate mannosyltransferase polypeptide 1, catalytic subunit -
Overview
Dolichol-phosphate mannose (Dol-P-Man) serves as a donor of mannosyl residues on the lumenal side of the endoplasmic reticulum (ER).Lack of Dol-P-Man results in defective surface expression of GPI-anchored proteins.Dol-P-Man is synthesized from GDP-mannose and dolichol-phosphate on the cytosolic side of the ER by the enzyme dolichyl-phosphate mannosyltransferase.Human DPM1 lacks a carboxy-terminal transmembrane domain and signal sequence and is regulated by DPM2. -
Synonyms
DPM1;dolichyl-phosphate mannosyltransferase polypeptide 1, catalytic subunit;dolichol-phosphate mannosyltransferase;CDGIE;MPDS;dolichol monophosphate mannose synthase;Dolichol phosphate mannose synthase;Dolichol-phosphate mannose synthase;Dolichyl phosphate beta D mannosyltransferase;dolichyl phosphate mannosyltransferase polypeptide 1;dolichyl phosphate mannosyltransferase polypeptide 1 catalytic subunit;Dolichyl-phosphate beta-D-mannosyltransferase;DPM synthase;DPM1_HUMAN;Mannose P dolichol synthase;Mannose-P-dolichol synthase;MPD synthase
Recombinant Proteins
- Human
- Zebrafish
- S.cerevisiae
- Ustilago maydis
- E.coli
- Mammalian Cell
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- E.coli expression system
- His
- GST
- Non
- His&ABP
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| DPM1-01H | Recombinant Human DPM1 Protein, His-Tagged | E.coli | Human | His | ||
| DPM1-1023Z | Recombinant Zebrafish DPM1 | Mammalian Cell | Zebrafish | His |
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| DPM1-2836H | Recombinant Human DPM1 Protein, GST-tagged | Wheat Germ | Human | GST |
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| DPM1-6835HCL | Recombinant Human DPM1 293 Cell Lysate | HEK293 | Human | Non |
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| DPM1-315H | Recombinant Human DPM1 Protein, His/ABP-tagged | E.coli | Human | His&ABP |
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| DPM1-4079HF | Recombinant Full Length Human DPM1 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 260 amino acids |
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| RFL29232SF | Recombinant Full Length Saccharomyces Cerevisiae Dolichol-Phosphate Mannosyltransferase(Dpm1) Protein, His-Tagged | E.coli expression system | S.cerevisiae | His | Full L. Full Length of Mature Protein (2-267) |
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| RFL7397UF | Recombinant Full Length Ustilago Maydis Dolichol-Phosphate Mannosyltransferase(Dpm1) Protein, His-Tagged | E.coli expression system | Ustilago maydis | His | Full L. Full Length (1-294) |
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Involved Pathway
DPM1 involved in several pathways and played different roles in them. We selected most pathways DPM1 participated on our site, such as N-Glycan biosynthesis,Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with DPM1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Metabolic pathways | RGN,ADSS,TPK1,Amy1,GNSA,ASMT,HPDB,NT5C1B-RDH14,DAK,NAT1 |
| N-Glycan biosynthesis | RPN1,DOLK,STT3B,MGAT5B,ALG13,MGAT2,MGAT5,DOLPP1,MAN1A2,ALG3 |
Protein Function
DPM1 has several biochemical functions, for example, alcohol binding,dolichyl-phosphate beta-D-mannosyltransferase activity,dolichyl-phosphate-mannose-protein mannosyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by DPM1 itself. We selected most functions DPM1 had, and list some proteins which have the same functions with DPM1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| dolichyl-phosphate-mannose-protein mannosyltransferase activity | SDF2,ALG5 |
| alcohol binding | CDIPT |
| dolichyl-phosphate beta-D-mannosyltransferase activity | ALG5 |
| mannose binding | CD209,BSG,MBL1,LMAN2L,MBL2,CLN5,M6PR,COLEC10,MRC1,CD209B |
| protein binding | AURKB,MLKL,RAP2A,CDKN1C,CREB3L1,GNPDA1,CTDSP2,RNF135,CD8B,ATP6V0A4 |
Interacting Protein
DPM1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DPM1 here. Most of them are supplied by our site. Hope this information will be useful for your research of DPM1.
ILK;DPM3;TDO2;MYC;PTP4A3;CIAO1;DPM2;TSC22D1;DPM3;TNFRSF14;BRF2
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