DPEP2
-
Official Full Name
dipeptidase 2 -
Overview
DPEP2 belongs to the membrane-bound dipeptidase (EC 3.4.13.19) family. These enzymes hydrolyze a variety of dipeptides,;including leukotriene D4, the beta-lactam ring of some antibiotics, and cystinyl-bis-glycine (cys-bis-gly) formed;during glutathione degradation (Habib et al., 2003 (PubMed 12738806)). -
Synonyms
DPEP2;dipeptidase 2;Dipeptidase2;DPEP 2;MBD 2;MBD2
Recombinant Proteins
- Human
- Rat
- Mouse
- E.coli
- Mammalian Cell
- Wheat Germ
- HEK293
- Human Cell
- In Vitro Cell Free System
- GST
- His
- Fc
- Non
- His&Fc&Avi
Involved Pathway
DPEP2 involved in several pathways and played different roles in them. We selected most pathways DPEP2 participated on our site, such as Aflatoxin activation and detoxification,Arachidonic acid metabolism,Biological oxidations, which may be useful for your reference. Also, other proteins which involved in the same pathway with DPEP2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| leukotriene biosynthesis | DPEP1 |
| Metabolism | ETFDH,DPEP1,UGT1B5,CYP4B1,HS3ST4,CYP2A7,OMD,SLC25A1A,SIN3B,B3GNT3 |
| Metabolism of lipids and lipoproteins | SPTLC1,CLPS,OSBP,ARSF,CYP11B1,APOA5,APOBB.1,CDS1,CYP24A1,EBP |
| Arachidonic acid metabolism | CYP4F2,LTC4S,PLA2G4C,CYP2B19,PLA2G2E,EPHX2,PTGES3,CBR1L,CYP2C37,ALOX5B.2 |
| Aflatoxin activation and detoxification | GGTLC1,CYP2A13,ACY3.2,ACY3,CYP2Y3,CYP3A4,CYP3C1,CYP1A2,CYP3A5,GGT6 |
| Synthesis of Leukotrienes (LT) and Eoxins (EX) | DPEP1,ALOX5B.2,ALOX5B.3,PTGR1,ALOX5AP |
| Biological oxidations | CYP2K22,ABHD10,NCOA2,CYP4F12,GLYAT,SLC35B2,GLYATL2,CYP2N13,CYP4B1,PRKRA |
Protein Function
DPEP2 has several biochemical functions, for example, dipeptidase activity,dipeptidyl-peptidase activity,metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by DPEP2 itself. We selected most functions DPEP2 had, and list some proteins which have the same functions with DPEP2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| dipeptidase activity | SCRN3,DPEP3,PEPD,NAALAD2,NAALADL1,CNDP1,SCRN1,CNDP2,FOLH1,SCRN2 |
| dipeptidyl-peptidase activity | DPP7,FAP,DPP4,DPEP3,DPP3,NAALAD2,PRCP,DPEP1,DPP8 |
| metal ion binding | CTDSPL,KSR1,ZNF423,PFKMB,CLCA2,SALL3,NDUFV2,MOB4,RORAB,TNNI1 |
| metalloexopeptidase activity | LAP3,DPEP3,NUDT16,NPEPL1,RNPEP,METAP2,METAP1,METAP1D,METAP2B,METAP2A |
Interacting Protein
DPEP2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DPEP2 here. Most of them are supplied by our site. Hope this information will be useful for your research of DPEP2.
uvrA
Resources
Related Services
Related Products
References
- Sabra, A; Bessoule, JJ; et al. Host-Pathogen Interaction and Signaling Molecule Secretion Are Modified in the dpp3 Knockout Mutant of Candida lusitaniae. INFECTION AND IMMUNITY 82:413-422(2014).
- Hast, BE; Goldfarb, D; et al. Proteomic Analysis of Ubiquitin Ligase KEAP1 Reveals Associated Proteins That Inhibit NRF2 Ubiquitination. CANCER RESEARCH 73:2199-2210(2013).
