DOK7
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Official Full Name
docking protein 7 -
Overview
The protein encoded by this gene is essential for neuromuscular synaptogenesis. The protein functions in aneural activation of muscle-specific receptor kinase, which is required for postsynaptic differentiation, and in the subsequent clustering of the acetylcholine receptor in myotubes. This protein can also induce autophosphorylation of muscle-specific receptor kinase. Mutations in this gene are a cause of familial limb-girdle myasthenia autosomal recessive, which is also known as congenital myasthenic syndrome type 1B. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2009] -
Synonyms
DOK7;docking protein 7;CMS1B;C4orf25;protein Dok-7;downstream of tyrosine kinase 7
Recombinant Proteins
- Rat
- Human
- Mouse
- E.coli
- Wheat Germ
- Mammalian Cell
- HEK293
- HEK293T
- In Vitro Cell Free System
- His
- GST
- Non
- His&Fc&Avi
- Myc&DDK
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| Dok7-205R | Recombinant Rat Dok7 Protein, His-tagged | E.coli | Rat | His | Trp63~Gly320 | |
| DOK7-2816H | Recombinant Human DOK7 Protein, GST-tagged | Wheat Germ | Human | GST |
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| DOK7-4766M | Recombinant Mouse DOK7 Protein | Mammalian Cell | Mouse | His |
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| DOK7-6843HCL | Recombinant Human DOK7 293 Cell Lysate | HEK293 | Human | Non |
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| DOK7-2487M | Recombinant Mouse DOK7 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| DOK7-2487M-B | Recombinant Mouse DOK7 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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| Dok7-2632M | Recombinant Mouse Dok7 Protein, Myc/DDK-tagged | HEK293T | Mouse | Myc&DDK |
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| DOK7-3767H | Recombinant Human DOK7 Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293T | Human | Myc&DDK |
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| DOK7-3946HF | Recombinant Full Length Human DOK7 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 298 amino acids |
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Involved Pathway
DOK7 involved in several pathways and played different roles in them. We selected most pathways DOK7 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with DOK7 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
DOK7 has several biochemical functions, for example, insulin receptor binding,lipid binding,protein kinase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by DOK7 itself. We selected most functions DOK7 had, and list some proteins which have the same functions with DOK7. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| insulin receptor binding | IGF1R,DOK5,GRB10,SHC1,INS1,IGF2,INS,PHIP,DOK3,DOK2 |
| lipid binding | RBP2A,PTGS2,APOL2,CADPS,SEC14L4,BAD,PSAP,ESYT3,STARD6,BPIFA5 |
| protein kinase binding | SPRED2,STK39,CHRNA7,RAD9A,TRIM22,DBF4B,EPHA1,CCNB1,SYK,JIP1 |
Interacting Protein
DOK7 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DOK7 here. Most of them are supplied by our site. Hope this information will be useful for your research of DOK7.
mpzl1;CRK;APPL1;ypel3;EFHC1;GABARAPL2
Resources
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References
- Witting, N; Crone, C; et al. Clinical and neurophysiological response to pharmacological treatment of DOK7 congenital myasthenia in an older patient. CLINICAL NEUROLOGY AND NEUROSURGERY 130:168-170(2015).
- Franco, A; Malhotra, N; et al. Publication bias in the social sciences: Unlocking the file drawer. SCIENCE 345:1502-1505(2014).
