DOCK7
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Official Full Name
dedicator of cytokinesis 7 -
Overview
Dock7 (Dedicator of cytokinesis 7), also known as Zir2, is a large (~240 kDa) protein involved in intracellular signalling networks. It is a member of the DOCK-C subfamily of the DOCK family of guanine nucleotide exchange factors (GEFs) which function as activators of small G proteins. Dock7 activates isoforms of the small G protein Rac. -
Synonyms
DOCK7;dedicator of cytokinesis 7;ZIR2;KIAA1771, ZIR2;OTTHUMP00000015338;dedicator of cytokinesis protein 7
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| DOCK7-28082TH | Recombinant Human DOCK7, His-tagged | E.coli | Human | His | 1823-2109 a.a. |
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| DOCK7-2808H | Recombinant Human DOCK7 Protein, GST-tagged | Wheat Germ | Human | GST |
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| DOCK7-504HCL | Recombinant Human DOCK7 cell lysate | Human | Non |
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| DOCK7-1370H | Recombinant Human DOCK7 Protein, His-tagged | E.coli | Human | His | Val1916-Leu2140 |
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| Dock7-1371R | Recombinant Rat Dock7 Protein, His-tagged | E.coli | Rat | His | Arg1815-Leu2118 |
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| DOCK7-3936HF | Recombinant Full Length Human DOCK7 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 624 amino acids |
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Involved Pathway
DOCK7 involved in several pathways and played different roles in them. We selected most pathways DOCK7 participated on our site, such as ErbB2/ErbB3 signaling events,Factors involved in megakaryocyte development and platelet production,Hemostasis, which may be useful for your reference. Also, other proteins which involved in the same pathway with DOCK7 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Factors involved in megakaryocyte development and platelet production | AKAP1B,GATA2A,KIF3A,MFN1,DOCK1,VPS45,ZFPM2A,HBB-Y,KIF2A,AKAP10 |
| Hemostasis | KIF2C,ABHD6B,TRPC7,ZFPM1,PLEK,SLC8A2A,GATA1,GATA2A,CFHL4,FCER1GL |
| ErbB2/ErbB3 signaling events | FMNL3,RNF41,CHRNE,CHRNA1 |
Protein Function
DOCK7 has several biochemical functions, for example, Rac GTPase binding,guanyl-nucleotide exchange factor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by DOCK7 itself. We selected most functions DOCK7 had, and list some proteins which have the same functions with DOCK7. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| guanyl-nucleotide exchange factor activity | FGD4,RANGRF,DIS3,PREX1,DOCK4B,RAPGEF5B,NET1,SH2D3C,FFAR1,DOCK8 |
| Rac GTPase binding | ARFIP2,SRGAP2B,SRGAP2,FMNL1,ARHGEF2,CDKL5,DVL1,EPS8,ITPKA,NOXA1 |
Interacting Protein
DOCK7 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DOCK7 here. Most of them are supplied by our site. Hope this information will be useful for your research of DOCK7.
USP19;YWHAG;USP7;RPP14;TK1;ANXA7;SNCA;CDKN1A;PPP2CB;BCL2L1;GRB7;SMN1;WHSC1L1;q9wmx2-pro_0000037548;RASSF10;N;LRCH4;MYC;YWHAZ;YWHAH
Resources
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References
- Schaker, K; Bartsch, S; et al. The Bipartite Rac1 Guanine Nucleotide Exchange Factor Engulfment and Cell Motility 1/Dedicator of Cytokinesis 180 (Elmo1/Dock180) Protects Endothelial Cells from Apoptosis in Blood Vessel Development. JOURNAL OF BIOLOGICAL CHEMISTRY 290:6408-6418(2015).
- Aydin, SE; Kilic, SS; et al. DOCK8 Deficiency: Clinical and Immunological Phenotype and Treatment Options - a Review of 136 Patients. JOURNAL OF CLINICAL IMMUNOLOGY 35:189-198(2015).
