DOCK3
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Official Full Name
dedicator of cytokinesis 3 -
Overview
This gene is specifically expressed in the central nervous system (CNS). It encodes a member of the DOCK (dedicator of cytokinesis) family of guanine nucleotide exchange factors (GEFs). This protein, dedicator of cytokinesis 3 (DOCK3), is also known as modifier of cell adhesion (MOCA) and presenilin-binding protein (PBP). The DOCK3 and DOCK1, -2 and -4 share several conserved amino acids in their DHR-2 (DOCK homology region 2) domains that are required for GEF activity, and bind directly to WAVE proteins [Wiskott-Aldrich syndrome protein (WASP) family Verprolin-homologous proteins] via their DHR-1 domains. The DOCK3 induces axonal outgrowth in CNS by stimulating membrane recruitment of the WAVE complex and activating the small G protein Rac1. This gene is associated with an attention deficit hyperactivity disorder-like phenotype by a complex chromosomal rearrangement. [provided by RefSeq, Aug 2010] -
Synonyms
DOCK3;dedicator of cytokinesis 3;PBP;MOCA;dedicator of cytokinesis protein 3;modifier of cell adhesion;presenilin-binding protein
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Involved Pathway
DOCK3 involved in several pathways and played different roles in them. We selected most pathways DOCK3 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with DOCK3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
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Protein Function
DOCK3 has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by DOCK3 itself. We selected most functions DOCK3 had, and list some proteins which have the same functions with DOCK3. You can find most of the proteins on our site.
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Interacting Protein
DOCK3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DOCK3 here. Most of them are supplied by our site. Hope this information will be useful for your research of DOCK3.
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