DOCK10
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Official Full Name
dedicator of cytokinesis 10 -
Overview
Dock10 (Dedicator of cytokinesis), also known as Zizimin3, is a large (~240 kDa) protein involved in intracellular signalling networks.It is a member of the DOCK-D subfamily of the DOCK family of guanine nucleotide exchange factors which function as activators of small G proteins. -
Synonyms
DOCK10;dedicator of cytokinesis 10;dedicator of cytokinesis protein 10;KIAA0694;ZIZ3;zizimin3;zizimin-3;protein zizimin 3;dopamine receptor interacting protein 2;DRIP2;Nbla10300;DKFZp781A1532
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| DOCK10-12117H | Recombinant Human DOCK10, His-tagged | E.coli | Human | His | 194-542a.a. | |
| DOCK10-2804H | Recombinant Human DOCK10 Protein, GST-tagged | Wheat Germ | Human | GST |
|
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| DOCK10-1365H | Recombinant Human DOCK10 Protein, His-tagged | E.coli | Human | His | Ala1945-Val2186 |
|
| Dock10-1366M | Recombinant Mouse Dock10 Protein, His-tagged | E.coli | Mouse | His | Ile2016-Val2187 |
|
| DOCK10-4070HF | Recombinant Full Length Human DOCK10 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 542 amino acids |
|
Involved Pathway
DOCK10 involved in several pathways and played different roles in them. We selected most pathways DOCK10 participated on our site, such as Factors involved in megakaryocyte development and platelet production,Hemostasis,Regulation of CDC42 activity, which may be useful for your reference. Also, other proteins which involved in the same pathway with DOCK10 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Hemostasis | S100A10A,CFHL3,NFE2,PDPN,CD84,IRF2,HBBE3,WDR1,DGKQ,DOCK9 |
| Factors involved in megakaryocyte development and platelet production | HBB-BH1,PHF21A,EHD1,HMG20B,IRF1B,KDM1A,KIF4A,HBB-Y,KIFAP3,DOCK8 |
| Regulation of CDC42 activity | DOCK9,RALBP1,ARHGEF25,DOCK6,SPATA13,ITSN2,BCAR3,ARHGAP17,MCF2L,DNMBP |
Protein Function
DOCK10 has several biochemical functions, for example, Rho GTPase binding,Rho guanyl-nucleotide exchange factor activity,molecular_function. Some of the functions are cooperated with other proteins, some of the functions could acted by DOCK10 itself. We selected most functions DOCK10 had, and list some proteins which have the same functions with DOCK10. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | GOLGA7,ARID5A,ARMCX1,SNX10,RASL10B,CDH15,TESC,TNNI3K,MT1G,AGGF1 |
| molecular_function | BNIP4,GLIPR1B,KERA,DEFA24,CLDN26,HEATR8,TMEM88B,VPS51,TMEM120B,MSMP |
| Rho guanyl-nucleotide exchange factor activity | ARHGEF15,ARHGEF3,ARHGEF7,PLEKHG3,ABR,MCF2L,PLEKHG6,FGD2,FGD3,DNMBP |
| Rho GTPase binding | DAAM1,AKAP13,DIAPH3,ROCK2,DOCK11,ROCK2A,FLNA,PARD6A,PFN1,ANTXR2A |
Interacting Protein
DOCK10 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DOCK10 here. Most of them are supplied by our site. Hope this information will be useful for your research of DOCK10.
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