DOC2B
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Official Full Name
double C2-like domains, beta -
Overview
There are at least two protein isoforms of the Double C2 protein,namely alpha (DOC2A) and beta (DOC2B), which contain two C2-like domains.DOC2A and DOC2B are encoded by different genes; these genes are at times confused with the unrelated DAB2 gene which was initially named DOC-2. DOC2B is expressed ubiquitously and is suggested to be involved in Ca(2+)-dependent intracellular vesicle trafficking in various types of cells. -
Synonyms
DOC2B;double C2-like domains, beta;DOC2BL, double C2 like domains, beta like;double C2-like domain-containing protein beta;Double C2 like domain containing protein beta;Doc2 beta;Doc2-beta;DOC2B_HUMAN;DOC2BL;Double C2 like domains beta;Double C2 like domains beta like;OTTMUSP00000006522;RP23 78H4.2;double C2-like domains, beta-like
Recombinant Proteins
- Human
- Rat
- Mouse
- E.coli
- Mammalian Cell
- Wheat Germ
- HEK293
- HEK293T
- In Vitro Cell Free System
- GST
- His
- Non
- His&Fc&Avi
- Myc&DDK
Involved Pathway
DOC2B involved in several pathways and played different roles in them. We selected most pathways DOC2B participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with DOC2B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
DOC2B has several biochemical functions, for example, calcium ion binding,calcium-dependent phospholipid binding,clathrin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by DOC2B itself. We selected most functions DOC2B had, and list some proteins which have the same functions with DOC2B. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| calcium ion binding | S100A3,EFCC1,ANXA10,BNIP2,GUCA1G,PEF1,DGKG,PCDH2AB5,LPCAT2,PLA2G2E |
| clathrin binding | SYT12,PICALMA,SYT2,CCDC167,PICALMB,SYT7B,TOM1L1,SMAP1,SYT1B,SYT10 |
| syntaxin binding | SYT16,SYT5,RAB11A,SYTL3,RPH3A,VPS11,CPLX4A,RPH3AL,NAPGA,TXLNG |
| calcium-dependent phospholipid binding | ANXA1B,AP1S2,SYT5,ANXA13L,ANXA5A,C2CD4B,SYTL4,RPH3A,ANXA10,SYT2 |
Interacting Protein
DOC2B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DOC2B here. Most of them are supplied by our site. Hope this information will be useful for your research of DOC2B.
Dlg4
Resources
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References
- Li, J; Cantley, J; et al. DOC2 isoforms play dual roles in insulin secretion and insulin-stimulated glucose uptake. DIABETOLOGIA 57:2173-2182(2014).
- Ramalingam, L; Lu, JP; et al. Doc2b serves as a scaffolding platform for concurrent binding of multiple Munc18 isoforms in pancreatic islet beta-cells. BIOCHEMICAL JOURNAL 464:251-258(2014).
