DNASE2
-
Official Full Name
deoxyribonuclease II, lysosomal -
Overview
This gene encodes a member of the DNase family. The protein, located in the lysosome, hydrolyzes DNA under acidic conditions and mediates the breakdown of DNA during erythropoiesis and apoptosis. Two codominant alleles have been characterized, DNASE2*L (low activity) and DNASE2*H (high activity), that differ at one nucleotide in the promoter region. The DNASE2*H allele is represented in this record. -
Synonyms
DNASE2;deoxyribonuclease II, lysosomal;DNL;DNL2;DNASE2A;Deoxyribonuclease-2-alpha;EC=3.1.22.1;Acid DNase;Deoxyribonuclease II alpha;DNase II alpha;Lysosomal DNase II;R31240_2;deoxyribonuclease-2-alpha;R31240_2;acid DNase;DNase II alpha;lysosomal DNase II;DNase II, lysosomal;deoxyribonuclease II alpha;NP_001366.1;EC 3.1.22.1;Acid DNase
Recombinant Proteins
- Human
- Cynomolgus
- Zebrafish
- Wheat Germ
- Mammalian Cell
- HEK293
- In Vitro Cell Free System
- E.coli
- HEK293T
- Mammalian cells
- GST
- His
- Non
- His&Fc&Avi
- Myc&DDK
- Flag
Involved Pathway
DNASE2 involved in several pathways and played different roles in them. We selected most pathways DNASE2 participated on our site, such as Clathrin derived vesicle budding,Lysosome,Lysosome Vesicle Biogenesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with DNASE2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Lysosome Vesicle Biogenesis | AP1S3A,AP4B1,CLVS2,CLVS1,CTSZ,BLOC1S1 |
| Lysosome | NAGLU,MANBA,ABCB9,NPC1,IDUA,FAM49BA,AP1M1,HGSNAT,GAA,FUCA1 |
| trans-Golgi Network Vesicle Budding | BLOC1S6,AP3S1,PICALMA,SNX9A,YIPF6,CLVS1,SH3D19,TPD52L1,CLVS2,AP4B1 |
| Clathrin derived vesicle budding | APPA,TCEAL4,TPD52L1,SH3D19,AP4B1,BLOC1S6,CLVS2,YIPF6,NAPAA,CLTB |
| Vesicle-mediated transport | MYO1C,RAB10,TRAPPC9,SEC16B,SEC23IP,ARCN1A,TPD52,GJD3,GJA8,TFR1B |
| Membrane Trafficking | TRAPPC2,GORASP1,GJD3,CLVS2,GOLGA2,AP1S3A,PICALMA,RALAA,CTSZ,EXOC8 |
Protein Function
DNASE2 has several biochemical functions, for example, DNA binding,deoxyribonuclease II activity. Some of the functions are cooperated with other proteins, some of the functions could acted by DNASE2 itself. We selected most functions DNASE2 had, and list some proteins which have the same functions with DNASE2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| deoxyribonuclease II activity | DNASE2B,DNASE2A |
| DNA binding | GSX2,ZNF398,ATRX,PKNOX1.1,ZNF521,ZNF671,E2F7,CDK5R2,POU5F1,ZEB2B |
Interacting Protein
DNASE2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DNASE2 here. Most of them are supplied by our site. Hope this information will be useful for your research of DNASE2.
RUVBL2;RUVBL1;cona_canen
Resources
Related Services
Related Products
References
