DNAJB6
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Official Full Name
DnaJ (Hsp40) homolog, subfamily B, member 6 -
Overview
This gene encodes a member of the DNAJ protein family. DNAJ family members are characterized by a highly conserved amino acid stretch called the J-domain and function as one of the two major classes of molecular chaperones involved in a wide range of cellular events, such as protein folding and oligomeric protein complex assembly. This family member may also play a role in polyglutamine aggregation in specific neurons. Alternative splicing of this gene results in multiple transcript variants; however, not all variants have been fully described. -
Synonyms
DNAJB6;DnaJ (Hsp40) homolog, subfamily B, member 6;dnaJ homolog subfamily B member 6;MRJ;DJ4;DnaJ;DNAJ B6;DNJB6_HUMAN;Heat shock protein J2;HHDJ1;HSJ-2;HSJ2;MSJ-1;MSJ1;DnaJ-like 2 protein
Recombinant Proteins
- Rhesus macaque
- Rat
- Chicken
- Human
- Mouse
- Mammalian Cell
- E.coli
- Wheat Germ
- HEK293
- E. coli
- HEK293T
- In Vitro Cell Free System
- His
- GST
- Non
- His&Fc&Avi
- Myc&DDK
Involved Pathway
DNAJB6 involved in several pathways and played different roles in them. We selected most pathways DNAJB6 participated on our site, such as Cellular response to heat stress,Cellular responses to stress,Regulation of HSF1-mediated heat shock response, which may be useful for your reference. Also, other proteins which involved in the same pathway with DNAJB6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Regulation of HSF1-mediated heat shock response | HSPA14,BAG3,HSPH1,DNAJC7,KIAA1967,ST13,RPS19BP1,C11orf73,DNAJC2,HSPA7 |
| Cellular response to heat stress | HSPA13,C11orf73,ST13,DNAJC2,HSPH1,HSBP1B,HDAC6,HSPA7,NUP50,BAG3 |
| Cellular responses to stress | HSBP1A,HIST2H3C,HIST3H2BB,HTATIP,HMGA1B,EP400,CBX8A,CEBPB,SUZ12A,CBX8B |
Protein Function
DNAJB6 has several biochemical functions, for example, ATPase activator activity,DNA binding,chaperone binding. Some of the functions are cooperated with other proteins, some of the functions could acted by DNAJB6 itself. We selected most functions DNAJB6 had, and list some proteins which have the same functions with DNAJB6. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | COQ7,GSK3B,FHIT,EPB49,NAALADL2,TRIM2,CD69,VHLL,MVK,ADAMTS13 |
| unfolded protein binding | TOMM20,SSUH2RS1,LRPAP1,RP2,HSP90AA1.2,CCT3,TCP1,CCT6B,TTC1,CALRL2 |
| chaperone binding | CTSC,GRPEL2,PARK2,CALR,DNAJB8,ERP29,TSC1,INS1,TIMM10,C1orf182 |
| heat shock protein binding | DNAJA3A,HSPA6,BAK1,PARK2,LMAN2,HSPA9,TPR,DLST,TFAM,PPID |
| DNA binding | HIST1H2B8,POLM,PEG10,POLR2I,FLYWCH1,CLSPN,ZEB2,POLR1D,RARAA,RBPJ |
| ATPase activator activity | TOR1AIP1,RAB4A,ATP1B3,AHSA1,AHSA1L,DNAJC15,DNAJB1,DNAJC10,TOR1AIP2,DNAJC24 |
Interacting Protein
DNAJB6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DNAJB6 here. Most of them are supplied by our site. Hope this information will be useful for your research of DNAJB6.
KRT18;MLF1;MLF2;DYSF;SGCG;BRMS1;HSPA8;UBA1
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