DMRT2
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Official Full Name
doublesex and mab-3 related transcription factor 2 -
Overview
The protein encoded by this gene belongs to the DMRT gene family, sharing a DM DNA-binding domain with Drosophila doublesex (dsx) and C. elegans mab3, genes involved in sex determination in these organisms. Also, this gene is located in a region of the human genome (chromosome 9p24.3) associated with gonadal dysgenesis and XY sex reversal. Hence this gene is one of the candidates for sex-determining gene(s) on chr 9. -
Synonyms
DMRT2;doublesex and mab-3 related transcription factor 2;doublesex- and mab-3-related transcription factor 2;terra like protein;Doublesex and mab 3 related transcription factor 2;Doublesex-like 2 protein;DSXL 2;DSXL2;DSXL-2;OTTHUMP00000020964;OTTHUMP00000020965;OTTHUMP00000020966;OTTHUMP00000020967;terra-like protein
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| DMRT2-2710H | Recombinant Human DMRT2 Protein, GST-tagged | Wheat Germ | Human | GST |
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| DMRT2-4650M | Recombinant Mouse DMRT2 Protein | Mammalian Cell | Mouse | His |
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| DMRT2-2415M | Recombinant Mouse DMRT2 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| DMRT2-2415M-B | Recombinant Mouse DMRT2 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
DMRT2 involved in several pathways and played different roles in them. We selected most pathways DMRT2 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with DMRT2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
DMRT2 has several biochemical functions, for example, DNA binding,RNA polymerase II regulatory region sequence-specific DNA binding,core promoter proximal region sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by DMRT2 itself. We selected most functions DMRT2 had, and list some proteins which have the same functions with DMRT2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| sequence-specific DNA binding | CREB3L3A,HLFA,LHX2B,HMX4,TLX3B,MEF2A,BCL11B,MNX2A,POU3F1,TRIM24 |
| RNA polymerase II regulatory region sequence-specific DNA binding | ZNF79,TFAP2D,SUV39H1,EOMES,RARG,HMX3,ZNF561,NME2,FERD3L,BARHL1B |
| transcription factor activity, sequence-specific DNA binding | FOXN2,TBX10,ZNF167,SPZ1,ZNF354B,SOX32,ZNF311,PHF1,TBPL2,KLF5 |
| core promoter proximal region sequence-specific DNA binding | DMRTC1B,DMRTA2,ZFP516,MIXL1,DMRTC1C2,KLF1,TFAP2A,SMAD4,CXXC1,DMRT3A |
| metal ion binding | BTR18,SP7,FDX1L,ZNF654,UNC13C,KLF16,ZFP319,SNRNP48,OSGEP,ZFP710 |
| DNA binding | ZNF559,ZBED3,NFE2L2,ZBTB1,KIF4,PAPD7,HOXB8B,SP100,ATRX,NKX3.3 |
| protein homodimerization activity | CEACAM1,PVRL1A,FAM109A,SYT14,TFRC,TOX3,WWTR1,SPATA24,TYRP1,Pdgfa&Pdgfb |
Interacting Protein
DMRT2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DMRT2 here. Most of them are supplied by our site. Hope this information will be useful for your research of DMRT2.
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References
- Shi, Y; Wang, Q; et al. Molecular identification of dmrt2 and dmrt5 and effect of sex steroids on their expressions in Chlamys nobilis. AQUACULTURE 426:21-30(2014).
- Liu, YC; Ferguson, JF; et al. Tissue-Specific RNA-Seq in Human Evoked Inflammation Identifies Blood and Adipose LincRNA Signatures of Cardiometabolic Diseases. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY 34:902-912(2014).
