DLX4

  • Official Full Name

    distal-less homeobox 4

  • Overview

    Many vertebrate homeo box-containing genes have been identified on the basis of their sequence similarity with Drosophila developmental genes. Members of the Dlx gene family contain a homeobox that is related to that of Distal-less (Dll), a gene expressed in the head and limbs of the developing fruit fly. The Distal-less (Dlx) family of genes comprises at least 6 different members, DLX1-DLX6. The DLX proteins are postulated to play a role in forebrain and craniofacial development. Three transcript variants have been described for this gene, however, the full length nature of one variant has not been described. Studies of the two splice variants revealed that one encoded isoform functions as a repressor of the beta-globin gene while the other isoform lacks that function.

  • Synonyms

    DLX4;distal-less homeobox 4;DLX7, DLX9;homeobox protein DLX-4;BP1;DLX8;beta protein 1;homeobox protein DLX-7;homeobox protein DLX-8;distal-less homeo box 7;distal-less homeo box 9;DLX7;DLX9

Recombinant Proteins

  • Human
  • Mouse
  • E.coli
  • Wheat Germ
  • Mammalian Cell
  • HEK293
  • In Vitro Cell Free System
  • HIS
  • GST
  • His
  • Non
  • His&Fc&Avi
Cat.# Product name Source (Host) Species Tag Protein Length Price
DLX4-068H Recombinant Human DLX4 Protein, HIS-tagged E.coli Human HIS
DLX4-2694H Recombinant Human DLX4 Protein, GST-tagged Wheat Germ Human GST
DLX4-4637M Recombinant Mouse DLX4 Protein Mammalian Cell Mouse His
DLX4-5388H Recombinant Human Distal-less Homeobox 4 E.coli Human Non 103-168 a.a.
DLX4-6904HCL Recombinant Human DLX4 293 Cell Lysate HEK293 Human Non
DLX4-6905HCL Recombinant Human DLX4 293 Cell Lysate HEK293 Human Non
DLX4-2406M Recombinant Mouse DLX4 Protein, His (Fc)-Avi-tagged HEK293 Mouse His&Fc&Avi
DLX4-2406M-B Recombinant Mouse DLX4 Protein Pre-coupled Magnetic Beads HEK293 Mouse
DLX4-4006HF Recombinant Full Length Human DLX4 Protein, GST-tagged In Vitro Cell Free System Human GST Full L. 240 amino acids

    Involved Pathway

    DLX4 involved in several pathways and played different roles in them. We selected most pathways DLX4 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with DLX4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein

    Protein Function

    DLX4 has several biochemical functions, for example, RNA polymerase II core promoter proximal region sequence-specific DNA binding,protein binding,sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by DLX4 itself. We selected most functions DLX4 had, and list some proteins which have the same functions with DLX4. You can find most of the proteins on our site.

    Function Related Protein
    transcription factor activity, sequence-specific DNA binding SPI1,IRF6,NKX6-1,TFCP2,PBX3B,PFDN1,HOXC5,PA2G4,TEAD2,POU2F2
    transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding GATA1,MYPOP,MZF1,HOXA2,NR1D1,SKIL,NKX6,ZNF217,ZFPM2,CREBBP
    sequence-specific DNA binding SIX4B,HOXA11,EOMES,NKX2.5,NR2C2,NR2F1B,E2F1,RORCA,ISL1L,GATAD1
    protein binding TIMM44,SIGIRR,ATP10A,EFHA1,LZTS2,TTC23L,MAP3K8,TSGA10IP,GCM1,TRIB3
    RNA polymerase II core promoter proximal region sequence-specific DNA binding CREB1,KLF17,TCF12,NFIA,FEZF2,EN1,GATA4,PGR,EBF2,CTCF

    Interacting Protein

    DLX4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DLX4 here. Most of them are supplied by our site. Hope this information will be useful for your research of DLX4.

    SP1;SMAD4;SMAD2;ABL1;FYN;SRC;NCK1;PLCG1;PIK3R1;CRK;GRB2

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