DLAT
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Official Full Name
dihydrolipoamide S-acetyltransferase -
Overview
This gene encodes component E2 of the multi-enzyme pyruvate dehydrogenase complex (PDC). PDC resides in the inner mitochondrial membrane and catalyzes the conversion of pyruvate to acetyl coenzyme A. The protein product of this gene, dihydrolipoamide acetyltransferase, accepts acetyl groups formed by the oxidative decarboxylation of pyruvate and transfers them to coenzyme A. Dihydrolipoamide acetyltransferase is the antigen for antimitochondrial antibodies. These autoantibodies are present in nearly 95% of patients with the autoimmune liver disease primary biliary cirrhosis (PBC). In PBC, activated T lymphocytes attack and destroy epithelial cells in the bile duct where this protein is abnormally distributed and overexpressed. PBC enventually leads to cirrhosis and liver failure. Mutations in this gene are also a cause of pyruvate dehydrogenase E2 deficiency which causes primary lactic acidosis in infancy and early childhood.[provided by RefSeq, Oct 2009] -
Synonyms
DLAT;dihydrolipoamide S-acetyltransferase;DLTA;PDCE2;PDC-E2;dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial;PBC;M2 antigen complex 70 kDa subunit;pyruvate dehydrogenase complex component E2;E2 component of pyruvate dehydrogenase complex;70 kDa mitochondrial autoantigen of primary biliary cirrhosis;dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex;dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex mitochondrial
Recombinant Proteins
- Zebrafish
- Rhesus macaque
- Rat
- Human
- Mouse
- Mammalian Cell
- Wheat Germ
- E.coli
- HEK293
- Insect Cells
- Yeast
- HEK293T
- In Vitro Cell Free System
- His
- GST
- Non
- His&Fc&Avi
- Myc&DDK
Involved Pathway
DLAT involved in several pathways and played different roles in them. We selected most pathways DLAT participated on our site, such as Biosynthesis of antibiotics,Carbon metabolism,Citrate cycle (TCA cycle), which may be useful for your reference. Also, other proteins which involved in the same pathway with DLAT were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Carbon metabolism | FBP1B,ACO2,ECHS1,HK2,pykF,DAK,AGXTA,CAT,PCCA,FBP1A |
| Pyruvate metabolism | hchA,LDHAL6A,GLO1,PDPR,ALDH3A2A,HAGH,ALDH2.1,PDK3,PDHA2,LDHBA |
| Metabolic pathways | ACER1,MTMR14,POLR2J3,DNMT3,NDUFS8B,COX8C,ITPKC,PLCH2,ALPP,APRT |
| Glycolysis / Gluconeogenesis | GAPDHS,TPI1A,GALM,ALDH9A1B,PKMA,BPGM,ALDOC,AKR1A1B,ACSS2,G6PC |
| Glycolysis and Gluconeogenesis | LDHAL6B,MPC2,BRP44,MPC1,SLC2A3 |
| Citrate cycle (TCA cycle) | IDH2,DLST,OGDHA,PCXB,OGDHL,SDHDA,SUCLA2,IDH3G,ACO2,MDH2 |
| Biosynthesis of antibiotics | DAO1,AK7,SDSL,EHHADH,CS,CYP51A1,AK8,NME6,ADH5,LDHAL6B |
| Metabolism | MED7,SLC19A2,ADH8A,DHCR7,MARCKSB,SLC25A16,CPNE1,PDK3,ACOT2,GRX2 |
Protein Function
DLAT has several biochemical functions, for example, dihydrolipoyllysine-residue acetyltransferase activity,protein binding,contributes_to pyruvate dehydrogenase (NAD+) activity. Some of the functions are cooperated with other proteins, some of the functions could acted by DLAT itself. We selected most functions DLAT had, and list some proteins which have the same functions with DLAT. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | SSB,C3orf39,ARNTL1A,POLR3C,SFRP5,PPP1R16A,DYRK1A,FAIM,MPP5,CAV2 |
| contributes_to pyruvate dehydrogenase (NAD+) activity | PDHX,DLD,PDHB |
Interacting Protein
DLAT has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DLAT here. Most of them are supplied by our site. Hope this information will be useful for your research of DLAT.
SIRT4;PDHB;SIRT3;PDHX;PRKD3;q9wmx2-pro_0000037548;midostaurin;ANXA1
Resources
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References
- Tian, J; Bryk, R; et al. Mycobacterium tuberculosis appears to lack alpha-ketoglutarate dehydrogenase and encodes pyruvate dehydrogenase in widely separated genes. MOLECULAR MICROBIOLOGY 57:859-868(2005).
