DHX58
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Official Full Name
DEXH (Asp-Glu-X-His) box polypeptide 58 -
Overview
A full-length cDNA encoding mouse LGP2 was cloned by computational analysis, RT-PCR, and RACE of liver and mammary tissue total RNA. And human LGP2 was also cloned. Yoneyama et al. have identified a DExD/H box-containing RNA helicase, retinoic acid inducible gene I (RIG-I), as an essential component of the sensor of intracellular dsRNA (1). Furthermore, two other DexD/H-box-containing RNA helicases, MDA5 and LGP2, were found in the mammalian database (2). MDA5 acts as a positive regulator in the virus-induced activation of type I IFN genes. On the other hand, LGP2 functions as a dominant-negative regulator of RIG-I/MDA5-mediated signaling. These molecules have critical roles for antiviral innate immune responses. -
Synonyms
DHX58;DEXH (Asp-Glu-X-His) box polypeptide 58;LGP2;D11LGP2;D11lgp2e;RNA helicase LGP2;OTTHUMP00000164729;ortholog of mouse D11lgp2;Probable ATP-dependent helicase LGP2;probable ATP-dependent RNA helicase DHX58;Protein D11Lgp2 homolog;RNA helicase LGP2;RLR;D11LGP2E3;RIG-I-like receptor LGP2;EC 3.6.4.13
Recombinant Proteins
- Human
- Mouse
- Zebrafish
- E.coli
- Wheat Germ
- Mammalian Cell
- Mammalian cell
- Mammalian cells
- HEK293
- In Vitro Cell Free System
- GST
- His
- Non
- Flag
- His&Flag&StrepII
- His&Fc&Avi
Involved Pathway
DHX58 involved in several pathways and played different roles in them. We selected most pathways DHX58 participated on our site, such as RIG-I-like receptor signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with DHX58 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| RIG-I-like receptor signaling pathway | IFNA8,TP-1,NLRX1,TBK1,NFKBIAA,IFNA12,MAPK8B,IFNA17,TRAF6,TRIM25 |
Protein Function
DHX58 has several biochemical functions, for example, ATP binding,DNA binding,double-stranded RNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by DHX58 itself. We selected most functions DHX58 had, and list some proteins which have the same functions with DHX58. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| DNA binding | UBN2B,NKX1.2LA,TOX,DMRT3,ZNF286A,FOXO3A,TAF6L,GLI1,CHD4A,BANF2 |
| double-stranded RNA binding | HMGB1,OASL,STAU1,RNASEN,TARBP2,ILF2,TFRC,STAU2,OASL2,TLR7 |
| protein binding | NR0B2,RUVBL2,FRMD8,NUDT14,IK,MMP15,FOXP1,SP1,HLA-DOA,HFE |
| ATP binding | SCN8A,ABCF3,MYO1EB,EPHA7,CLK4,CDKL1,PRKAG1,PEX1,BSK146,GK5 |
| helicase activity | DHX57,DHX33,DHX36,DDX39AA,MCM3L,EIF4A2,DDX19,CHD7,DNA2,MCM6L |
| zinc ion binding | RNF139,TRIM35-36,PHF13,GATA5,MICALL2A,BHMT,PRICKLE2B,RARB,LIMCH1,TRIM35-34 |
| single-stranded RNA binding | PIWIL1,A1CF,AGO1,TLR7,DDX58,STRBP,AGO2,CBX8,IFIT5,CBX7 |
Interacting Protein
DHX58 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DHX58 here. Most of them are supplied by our site. Hope this information will be useful for your research of DHX58.
NKRF;EIF2AK2;EIF6;DHX30;STAU2;AGO2;DICER1;P/V/C;P/V;P/V;P/V
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References
- Kreit, M; Paul, S; et al. Inefficient Type I Interferon-Mediated Antiviral Protection of Primary Mouse Neurons Is Associated with the Lack of Apolipoprotein L9 Expression. JOURNAL OF VIROLOGY 88:3874-3884(2014).
- Velazguez, AFC; Corby, J; et al. Design and cloning of fluorescent human helicase DHX58 (LGP2): Building the tools to study viral helicases. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY 247:-(2014).
