DHX36

  • Official Full Name

    DEAH (Asp-Glu-Ala-His) box polypeptide 36

  • Overview

    This gene is a member of the DEAH-box family of RNA-dependent NTPases which are named after the conserved amino acid sequence Asp-Glu-Ala-His in motif II. The protein encoded by this gene has been shown to enhance the deadenylation and decay of mRNAs with 3-UTR AU-rich elements (ARE-mRNA). The protein has also been shown to resolve into single strands the highly stable tetramolecular DNA configuration (G4) that can form spontaneously in guanine-rich regions of DNA. Alternative splicing results in multiple transcript variants encoding different isoforms.

  • Synonyms

    DHX36;DEAH (Asp-Glu-Ala-His) box polypeptide 36;DDX36, DEAD/H (Asp Glu Ala Asp/His) box polypeptide 36;probable ATP-dependent RNA helicase DHX36;KIAA1488;MLEL1;G4 resolvase-1;MLE-like protein 1;DEAH box protein 36;DEAD/H (Asp-Glu-Ala-Asp/His) bo

Recombinant Proteins

  • Mouse
  • Human
  • Mammalian Cell
  • HEK293T
  • HEK293
  • Mammalian cells
  • E.coli
  • His
  • Myc&DDK
  • His&Fc&Avi
  • Flag
  • His&Myc

    Involved Pathway

    DHX36 involved in several pathways and played different roles in them. We selected most pathways DHX36 participated on our site, such as RNA degradation, which may be useful for your reference. Also, other proteins which involved in the same pathway with DHX36 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    RNA degradation PFKL,CNOT3A,CNOT6L,ENO3,PABPC4,DCPS,TOB2,RQCD1,TOB1B,WDR61

    Protein Function

    DHX36 has several biochemical functions, for example, ATP binding,ATP-dependent RNA helicase activity,ATP-dependent helicase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by DHX36 itself. We selected most functions DHX36 had, and list some proteins which have the same functions with DHX36. You can find most of the proteins on our site.

    Function Related Protein
    histone deacetylase binding GMNN,BRMS1L,TOP2B,RUNX2,HOXA10,RELA,TCF21,NKX2-5,CAMTA2,D7ERTD443E
    poly(A) RNA binding TDRD9,HIST1H4J,BAG4,IGF2BP2,PSIP1,EPPK1,HHATL,FRG1,C1orf35,RPL7L1
    ATP-dependent RNA helicase activity FAM120B,EIF4A2,UPF1,TDRD9,DDX18,DDX27,PL10,DDX3Y,DDX56,ACTG2
    ATP binding MYO7A,PRPS2,PRPS1L1,TOP2A,NLRP3,CDK1,SRPK1B,ERN2,ABCA13,MAP3K14
    DNA-dependent ATPase activity ERCC6,RAD51C,SMARCAL1,MSH6,MSH5,XRCC2,SMARCA2,MSH2,DMC1,RAD51D
    G-quadruplex DNA binding WRN,LONP1,BLM
    ATP-dependent helicase activity TTF2,RTEL1,ERCC6L2,CHD4A,DHX37,RECQL5,SNRNP200,CHD6,BLM
    transcription regulatory region DNA binding TCF7,TNF,TAF7L,GATA6,FOXA2,HIVEP3,SIX1,MZF1,MTERF3,GATA3
    double-stranded RNA binding DHX58,TLR8,ADARB1,BARHL1,DDX58,MBNL1,YRDC,ELAVL1,DICER1,OASL

    Interacting Protein

    DHX36 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DHX36 here. Most of them are supplied by our site. Hope this information will be useful for your research of DHX36.

    Hmga2;Ago2

    Resources

    References

    • Yoo, JS; Takahasi, K; et al. DHX36 Enhances RIG-I Signaling by Facilitating PKR-Mediated Antiviral Stress Granule Formation. PLOS PATHOGENS 10:-(2014).
    • Booy, EP; Howard, R; et al. The RNA helicase RHAU (DHX36) suppresses expression of the transcription factor PITX1. NUCLEIC ACIDS RESEARCH 42:3346-3361(2014).

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