DEFB103B
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Official Full Name
defensin, beta 103B -
Overview
Human BD-3, also known as Beta-Defensin 3, is a 67 amino acid cytokine protein encoded by the DEFB103A gene located at locus 8p23.1 on chromosome 8. After signal sequence processing and maturation, the cytokine becomes 45 amino acid residues long (from 23 to 67). Human BD-3 is known to exhibit antimicrobial activity against Gram-positive bacteria, S.aureus and S.pyogenes, Gram-negative bacteria P.aeruginosa and E.coli and the yeast C.albicans. Moreover, the cytokine kills multiresistant S.aureus and vancomycin-resistant E.faecium. This particular BD protein is expressed highly in skin and tonsils, and to a lesser extent in trachea, uterus, kidney, thymus, adenoid, pharynx and tongue. It has much lower expression in salivary glands, bone marrow, colon, stomach, polyps and larynx along with no expression in the small intestine. Furthermore, induction of BD-3 is achieved through bacterial infection or detection of lipopolysaccharides (LPS) and by IFN-γ. -
Synonyms
BD-3;DEFB103;DEFB3;HBD3;HBP3;beta-defensin 103;beta-defensin 3;defensin, beta 103;defensin-like protein
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Involved Pathway
DEFB103B involved in several pathways and played different roles in them. We selected most pathways DEFB103B participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with DEFB103B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
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Protein Function
DEFB103B has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by DEFB103B itself. We selected most functions DEFB103B had, and list some proteins which have the same functions with DEFB103B. You can find most of the proteins on our site.
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Interacting Protein
DEFB103B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DEFB103B here. Most of them are supplied by our site. Hope this information will be useful for your research of DEFB103B.
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