DDX3X

  • Official Full Name

    DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, X-linked

  • Overview

    DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which interacts specifically with hepatitis C virus core protein resulting a change in intracellular location. This gene has a homolog located in the nonrecombining region of the Y chromosome. The protein sequence is 91% identical between this gene and the Y-linked homolog.

  • Synonyms

    ATP dependent RNA helicase DDX3X;DEAD box protein 3 X-chromosomal;DEAD box X isoform;Fibroblast Growth Factor Inducible 14;Fin14;Helicase like protein 2;HLP2

Recombinant Proteins

  • Human
  • Chicken
  • Mouse
  • Wheat Germ
  • Mammalian Cell
  • HEK293
  • Mamanlian cells
  • Yeast
  • Insect cells
  • E.coli
  • HEK293T
  • GST
  • His
  • Myc&DDK
  • Non
  • Flag
  • His&Myc
  • N-His&C-Myc
  • His&B2M
Cat.# Product name Source (Host) Species Tag Protein Length Price
DDX3X-28325TH Recombinant Human DDX3X protein, GST-tagged Wheat Germ Human GST 1-55 a.a.
DDX3X-2498C Recombinant Chicken DDX3X Mammalian Cell Chicken His
DDX3X-257H Recombinant Human DDX3X protein, MYC/DDK-tagged HEK293 Human Myc&DDK 44-522 a.a.
DDX3X-7007HCL Recombinant Human DDX3X 293 Cell Lysate HEK293 Human Non
DDX3X-1427HFL Recombinant Full Length Human DDX3X protein, Flag-tagged Mamanlian cells Human Flag Full L.
DDX3X-2214H Recombinant Human DDX3X protein, His&Myc-tagged Yeast Human His&Myc 2-662aa
DDX3X-2215H Recombinant Human DDX3X protein(2-662aa), His&Myc-tagged Insect cells Human N-His&C-Myc 2-662aa
DDX3X-2222H Recombinant Human DDX3X Protein (2-662 aa), His-B2M-tagged E.coli Human His&B2M 2-662 aa
Ddx3x-2506M Recombinant Mouse Ddx3x Protein, Myc/DDK-tagged HEK293T Mouse Myc&DDK

    Involved Pathway

    DDX3X involved in several pathways and played different roles in them. We selected most pathways DDX3X participated on our site, such as Hepatitis B,RIG-I-like receptor signaling pathway,TNF-alpha/NF-kB Signaling Pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with DDX3X were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Viral carcinogenesis SP100,HIST1H4L,CDC42,MAPK1,STAT5A,CCNA1,PRKACG,HDAC1,GTF2H4,IRF7
    TNF-alpha/NF-kB Signaling Pathway COPS3,SMARCC2,TRPC4AP,LRPPRC,FAF1,UNC5CL,PFDN2,DAP,AKAP8,RNF25
    Hepatitis B PIK3R1,MAP2K2,NRAS,ATP6AP1,BCL2,RAF1,FADD,NFATC1,CREB3L2,STAT5A
    RIG-I-like receptor signaling pathway IL-8,MAPK12,IFNE,IFIH1,MAPK12B,ATG5,NFKBIAB,MAPK8,IL8L2,IL8L1

    Protein Function

    DDX3X has several biochemical functions, for example, ATP binding,ATP-dependent DNA helicase activity,ATP-dependent RNA helicase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by DDX3X itself. We selected most functions DDX3X had, and list some proteins which have the same functions with DDX3X. You can find most of the proteins on our site.

    Function Related Protein
    RNA stem-loop binding CPEB3,EPRS,DAZAP1
    RNA binding RBM39B,RNASEL,RBM4B,ZMAT4,NHP2L1A,CNP,DCP2,KHDC1C,FXR2,HNRNPA1L2
    eukaryotic initiation factor 4E binding OTX2,EIF4EBP3L,EIF4G1,EIF4EBP1,EIF4EBP2,GRA,ANGEL1,HHEX,LARP1,EIF4EBP3
    transcription factor binding MED25,PITX2,DIP2A,NFKB1,LMO4,BCL3,HDAC11,HEYL,NR0B2A,DNAJA3
    protein binding PPP3CA,PPP1R12B,ALPI,SOX15,MPP1,AURKB,CKM,PPFIA1,EIF4H,CNOT10
    poly(A) binding PABPN1,TIA1,SYNCRIP,PABPC3,PABPC4,RBPMS,KHDRBS2,HNRNPDL,HNRPDL,PABPC1
    ATP-dependent DNA helicase activity GTF2H4,DHX9,XRCC5,FBXO18,BLM,CHD2,ERCC3,ERCC2,CHST13,G3BP1
    ribosomal small subunit binding DHX29,PTCD3,NPM1,PIM1,NME1,CPEB2,ERAL1,MTIF3
    ATP binding FARSA,ABCA4,EPHA8,PCXA,ATP12A,TTLL2,NMNAT1,PKN1,DHX58,MYH11A

    Interacting Protein

    DDX3X has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DDX3X here. Most of them are supplied by our site. Hope this information will be useful for your research of DDX3X.

    p27958-pro_0000037566;PABPC1

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