DDX21
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Official Full Name
DEAD (Asp-Glu-Ala-Asp) box helicase 21 -
Overview
DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which is an antigen recognized by autoimmune antibodies from a patient with watermelon stomach disease. This protein unwinds double-stranded RNA, folds single-stranded RNA, and may play important roles in ribosomal RNA biogenesis, RNA editing, RNA transport, and general transcription. -
Synonyms
DDX21;DEAD (Asp-Glu-Ala-Asp) box helicase 21;DEAD (Asp Glu Ala Asp) box polypeptide 21 , DEAD/H (Asp Glu Ala Asp/His) box polypeptide 21;nucleolar RNA helicase 2;GURDB;RH II/GU;gu-alpha;Gu protein;DEAD box protein 21;RNA helicase II/Gu
Recombinant Proteins
- Human
- Rat
- Zebrafish
- Mouse
- E.coli
- Mammalian Cell
- Wheat Germ
- HEK293
- Mammalian cells
- HEK293T
- In Vitro Cell Free System
- GST
- His
- Non
- His&Fc&Avi
- Flag
- Myc&DDK
Involved Pathway
DDX21 involved in several pathways and played different roles in them. We selected most pathways DDX21 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with DDX21 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
DDX21 has several biochemical functions, for example, 7SK snRNA binding,ATP binding,ATP-dependent RNA helicase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by DDX21 itself. We selected most functions DDX21 had, and list some proteins which have the same functions with DDX21. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| 7SK snRNA binding | HEXIM2,HEXIM1 |
| poly(A) RNA binding | EIF1B,SRP68,FAM32A,PPP1R10,SAP18,LGALS1,RBM42,C22orf28,WDR3,RRP36 |
| ATP-dependent RNA helicase activity | EIF4A2,DDX19,DDX6,CHST13,DDX49,DHX35,DHX33,DDX5,DDX41,DHX57 |
| rRNA binding | RPS9,RPL12,MRPL20,RPS18,MRPL16,RPL11,MRPS17,RNASEL,RPS11,EMG1 |
| ATP binding | KSR2,CLPB,QRSL1,KIF5C,DNAH14,HSPA4B,NARS2,MAPK1,PAK7,UCKL1 |
| double-stranded RNA binding | ZFP346,LRRFIP1,MSN,YRDC,MTDH,ZNF346,TLR7,ADARB1,ACTN1,CLTC |
| protein binding | PMF1,TRIM42,CLPP,INHBB,BCLAF1,USP13,KRT14,MTCH1,GALT,HMGB1 |
| snoRNA binding | TBL3,NOP10,UTP15,IMP4,IMP3,NUDT7,HEATR1,NUDT1,NOP58,NOP56 |
Interacting Protein
DDX21 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DDX21 here. Most of them are supplied by our site. Hope this information will be useful for your research of DDX21.
YBX1;JUN;KPNA3;TERF2;SRPK2;ESR1;TOP1;RTCA;PSTPIP1
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