DDX18
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Official Full Name
DDX18 DEAD (Asp-Glu-Ala-Asp) box polypeptide 18 -
Overview
DDX18 protein (670aa 75.4KDa) is a putative ATP-dependent RNA helicase since it possesses a DEAD box motif characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD).RNA helicases which may play a role in ribosome biogenesis. DDX18 acts as a cofactor for XPO1-mediated nuclear export of incompletely spliced HIV-1 Rev RNAs. It was also involved in HIV-1 replication and interacts specifically with hepatitis C virus core protein resulting in a change in intracellular location. -
Synonyms
DDX18;DEAD (Asp-Glu-Ala-Asp) box polypeptide 18;DEAD/H (Asp Glu Ala Asp/His) box polypeptide 18 (Myc regulated);ATP-dependent RNA helicase DDX18;MrDb;DEAD box protein 18;Myc-regulated DEAD box protein;DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 18 (Myc-regulated);FLJ33908
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| DDX18-2759H | Recombinant Human DDX18 protein, His-tagged | E.coli | Human | His | ||
| DDX18-2466H | Recombinant Human DDX18 Protein, GST-tagged | Wheat Germ | Human | GST |
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| DDX18-864Z | Recombinant Zebrafish DDX18 | Mammalian Cell | Zebrafish | His |
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| DDX18-7019HCL | Recombinant Human DDX18 293 Cell Lysate | HEK293 | Human | Non |
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| DDX18-1395H | Recombinant Human DDX18 Protein, His-tagged | E.coli | Human | His |
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| DDX18-2529HF | Recombinant Full Length Human DDX18 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 670 amino acids |
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Involved Pathway
DDX18 involved in several pathways and played different roles in them. We selected most pathways DDX18 participated on our site, such as Validated targets of C-MYC transcriptional activation, which may be useful for your reference. Also, other proteins which involved in the same pathway with DDX18 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Validated targets of C-MYC transcriptional activation | IREB2,MYCT1,MTDH,SERPINI1,NDUFAF2,PDCD10,MINA,LIN28B,PRDX3,PEG10 |
Protein Function
DDX18 has several biochemical functions, for example, ATP binding,ATP-dependent RNA helicase activity,poly(A) RNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by DDX18 itself. We selected most functions DDX18 had, and list some proteins which have the same functions with DDX18. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATP-dependent RNA helicase activity | DDX56,ACTG2,BAT1,DDX54,DDX47,DHX37,CHST13,DHX33,DHX38,DHX9 |
| protein binding | SULT1B1,KRTAP4-11,TMEM149,SOX10,HPSE,ZFYVE1,CD28,A1CF,CDKN2A,SID4 |
| ATP binding | P2RX1,ADCY1,ATP2C1,NSF,SRX1,DHX35,SMC1AL,KIF23,LATS1,QRSL1 |
| poly(A) RNA binding | PPRC1,TRIM25,PEBP1,UTP11L,CORO1A,DZIP3,BCCIP,C9orf114,RPSA,Txn1 |
Interacting Protein
DDX18 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DDX18 here. Most of them are supplied by our site. Hope this information will be useful for your research of DDX18.
ESR1;PINX1;MTA1;CRMP1;INADL;ssrna_ug
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