DDX11

  • Official Full Name

    DEAD/H (Asp-Glu-Ala-Asp/His) box helicase 11

  • Overview

    DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which is an enzyme that possesses both ATPase and DNA helicase activities. This gene is a homolog of the yeast CHL1 gene, and may function to maintain chromosome transmission fidelity and genome stability. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

  • Synonyms

    DDX11;DEAD/H (Asp-Glu-Ala-Asp/His) box helicase 11;DEAD/H (Asp Glu Ala Asp/His) box polypeptide 11 , DEAD/H (Asp Glu Ala Asp/His) box polypeptide 11 (S.cerevisiae CHL1 like helicase);probable ATP-dependent RNA helicase DDX11;CHL1;CHL1 like helicase

Recombinant Proteins

  • Human
  • Zebrafish
  • Mouse
  • E.coli
  • Mammalian Cell
  • Wheat Germ
  • HEK293
  • GST
  • His
  • Non
  • His&Fc&Avi
Cat.# Product name Source (Host) Species Tag Protein Length Price
DDX11-11890H Recombinant Human DDX11, GST-tagged E.coli Human GST N-term-345a.a.
DDX11-1711Z Recombinant Zebrafish DDX11 Mammalian Cell Zebrafish His
DDX11-28322TH Recombinant Human DDX11, GST-tagged Wheat Germ Human GST
DDX11-4399M Recombinant Mouse DDX11 Protein Mammalian Cell Mouse His
DDX11-454HCL Recombinant Human DDX11 cell lysate Human Non
DDX11-2263M Recombinant Mouse DDX11 Protein, His (Fc)-Avi-tagged HEK293 Mouse His&Fc&Avi
DDX11-2263M-B Recombinant Mouse DDX11 Protein Pre-coupled Magnetic Beads HEK293 Mouse

    Involved Pathway

    DDX11 involved in several pathways and played different roles in them. We selected most pathways DDX11 participated on our site, such as IRE1alpha activates chaperones,Metabolism of proteins,Unfolded Protein Response (UPR), which may be useful for your reference. Also, other proteins which involved in the same pathway with DDX11 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Metabolism of proteins FBXW5,TIMM21,CXXC1,MUC15,CPB1,CCT6A,ST6GAL2B,PPP6C,LMAN2L,GNE
    Unfolded Protein Response (UPR) WIPI1,KLHDC3,KDELR3,YIF1A,DNAJB9,SEC63,YY2,CXXC1,HDGF,PDIA6
    IRE1alpha activates chaperones CXXC1,DNAJB9,KDELR3,SEC63,FKBP14,HYOU1,ASNA1,YIF1A,CTDSP2,TPP1
    XBP1(S) activates chaperone genes TPP1,SEC63,PDIA6,FKBP14,WIPI1,CXXC1,YIF1A,SERP1,C19orf10,DNAJB9

    Protein Function

    DDX11 has several biochemical functions, for example, 4 iron, 4 sulfur cluster binding,ATP binding,ATP-dependent DNA helicase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by DDX11 itself. We selected most functions DDX11 had, and list some proteins which have the same functions with DDX11. You can find most of the proteins on our site.

    Function Related Protein
    ATP-dependent DNA helicase activity WRN,XRCC5,ERCC2,CHD1,ERCC3,CHD4,BLM,DHX9,GTF2H4,RUVBL2
    helicase activity UPF1,SETX,EIF4A2,DDX19B,DQX1,DDX19,DDX39AA,DDX39,DHX37,HELZ
    single-stranded DNA binding POLR2G,RAD51B,NABP2,NME2,YBX1,NCL,HNRNPA1,LONP1,RTF1,RAD51L3
    protein binding USP6,SCAMP1,TDO2,AKR1B10,MOCOS,RNF175,COMMD7,EEF1E1,SNTB1,GATC
    double-stranded DNA binding RAD51B,TDG,KIN,APTX,MEN1,HNRNPDL,RAD51L1,HMGB1,SP8B,DDX58
    RNA binding SRRM4,DHX36,SPI1,NANOS1,D19BWG1357E,AHCYL1,ZFML,RAVER2,TDRKH,RPL14
    4 iron, 4 sulfur cluster binding DPYD,ERCC2,NDUFS8B,NFU1,NDUFS2,PRIM2,ACO2,SDHB,NUBP2,REV3L
    DNA-dependent ATPase activity SMARCAL1,MSH3,ERCC6,IGHMBP2,RAD51B,RAD51C,TTF2,MSH6,MSH2,DHX36
    ATP binding PAPD4,C10orf2,ERBB4A,UBE2R2,KIF26A,PHKG1A,ROR2,PAPOLA,CSNK1E,LRRK1

    Interacting Protein

    DDX11 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DDX11 here. Most of them are supplied by our site. Hope this information will be useful for your research of DDX11.

    KAT7;PFN2

    Resources

    Research Area

    Immunoglobulin Superfamily CAMs

    References

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