DCTN1

  • Official Full Name

    dynactin 1

  • Overview

    This gene encodes the largest subunit of dynactin, a macromolecular complex consisting of 10 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. Dynactin is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit interacts with dynein intermediate chain by its domains directly binding to dynein and binds to microtubules via a highly conserved glycine-rich cytoskeleton-associated protein (CAP-Gly) domain in its N-terminus. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. Mutations in this gene cause distal hereditary motor neuronopathy type VIIB (HMN7B) which is also known as distal spinal and bulbar muscular atrophy (dSBMA).

  • Synonyms

    DCTN1;dynactin 1;dynactin 1 (p150, Glued (Drosophila) homolog);dynactin subunit 1;p150 glued homolog (Drosophila);150 kDa dynein-associated polypeptide;dynactin 1 (p150, glued homolog, Drosophila);P135;DP-150;DAP-150

Recombinant Proteins

  • Human
  • Rat
  • Chicken
  • E.coli
  • Mammalian Cell
  • Wheat Germ
  • HEK293
  • In Vitro Cell Free System
  • His&SUMO
  • His
  • GST
  • Non
  • His&Fc&Avi
Cat.# Product name Source (Host) Species Tag Protein Length Price
DCTN1-1184H Recombinant Human DCTN1 Protein, His-SUMO-tagged E.coli Human His&SUMO 213-547 a.a.
DCTN1-1800R Recombinant Rat DCTN1 Protein Mammalian Cell Rat His
DCTN1-2410H Recombinant Human DCTN1 Protein, GST-tagged Wheat Germ Human GST
DCTN1-27132TH Recombinant Human DCTN1, His-tagged E.coli Human His 22-291 a.a.
DCTN1-3018C Recombinant Chicken DCTN1 Mammalian Cell Chicken His
DCTN1-7043HCL Recombinant Human DCTN1 293 Cell Lysate HEK293 Human Non
DCTN1-1458R Recombinant Rat DCTN1 Protein, His (Fc)-Avi-tagged HEK293 Rat His&Fc&Avi
DCTN1-1458R-B Recombinant Rat DCTN1 Protein Pre-coupled Magnetic Beads HEK293 Rat
DCTN1-2938HF Recombinant Full Length Human DCTN1 Protein, GST-tagged In Vitro Cell Free System Human GST Full L. 198 amino acids

    Involved Pathway

    DCTN1 involved in several pathways and played different roles in them. We selected most pathways DCTN1 participated on our site, such as Adaptive Immune System,Anchoring of the basal body to the plasma membrane,Assembly of the primary cilium, which may be useful for your reference. Also, other proteins which involved in the same pathway with DCTN1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Centrosome maturation MAPRE1B,CEP135,CDK11B,TUBGCP5,PLK4,TUBG1,TUBGCP3,NEDD1,CKAP5,NUMA1
    G2/M Transition ODF2,NUMA1,CEP290,CDK11B,DCTN3,OFD1,CEP152,MAPRE1,CENPJ,TUBGCP4
    Huntingtons disease NDUFA11,NDUFA2,NRF1,COX6B1,COX5B,DNAH5,POLR2I,ATP5B,NDUFV3,ATP5J
    Cell cycle CEP164,ANAPC5,RAD21,MAPRE1,CDKN1BA,ORC3L,CUL1B,ZBTB17,MAPRE1B,KIF18A
    Anchoring of the basal body to the plasma membrane TUBG1,BBS13,CEP89,TCTN1,MAPRE1A,CEP78,TCTN3,CEP290,OFD1,MARK4
    Adaptive Immune System TPP2,SIGLEC6,KLC3,RAP1GAP2,THEM4,RBCK1,FBXO17,RNF6,LRRC41,CTSC
    Assembly of the primary cilium ATAT1,PCM1,TUBG1,IQCB1,NDE1,ODF2,OST4,IFT52,TTC8,BBS5
    Cell Cycle, Mitotic SPC24,ACTR1A,APITD1,MYCA,CENPK,DCTN1A,GINS4,PANE1,NCAPH2,GINS2

    Protein Function

    DCTN1 has several biochemical functions, for example, dynein binding,motor activity,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by DCTN1 itself. We selected most functions DCTN1 had, and list some proteins which have the same functions with DCTN1. You can find most of the proteins on our site.

    Function Related Protein
    motor activity MYH4,KIF5A,DYNLT1,MYO6A,KIF1C,SMYHC1,MYH1B,KLC1,MYH7B,DNALC4
    dynein binding ATMIN,SNCA,WDR81,SERPINB1A,SMC3,DNAAF1,PAFAH1B1,PAFAH1B1B,LRRC50,PAFAH1B1A
    protein binding UNC119B,FBXW8,KIF18B,SCRT1,NR3C1,KNG1,DNAAF2,MYCN,ERBB4,GSTP1

    Interacting Protein

    DCTN1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DCTN1 here. Most of them are supplied by our site. Hope this information will be useful for your research of DCTN1.

    Hap1;BBS4;MAPT;Dctn1;Dctn2;Dctn3

    Resources

    Research Area

    ALS Related Molecules
    Microtubules

    References

    Reviews

    Write a review

    Q&As

    Ask a question

    Ask a Question for All DCTN1 Products

    Required fields are marked with *

    My Review for All DCTN1 Products

    Required fields are marked with *