DCT
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Official Full Name
dopachrome tautomerase (dopachrome delta-isomerase, tyrosine-related protein 2) -
Overview
Dopachrome tautomerase (dopachrome delta-isomerase, tyrosine-related protein 2), also known as DCT, is a human gene . Its expression is regulated by the microphthalmia-associated transcription factor (MITF). -
Synonyms
DCT;dopachrome tautomerase (dopachrome delta-isomerase, tyrosine-related protein 2);TYRP2;L-dopachrome tautomerase;L dopachrome tautomerase;Dopachrome delta isomerase;Dopachrome tautomerase;Dopachrome tautomerase dopachrome delta isomerase, tyrosine related protein 2;DT;EC 5.3.3.12;L dopachrome Delta isomerase;L-dopachrome Delta-isomerase;TRP 2;TRP-2;TRP2;Tyrosinase related protein 2;Tyrosinase-related protein 2;TYRP2_HUMAN;OTTHUMP00000018553;dopachrome delta-isomerase
Recombinant Proteins
- Human
- Mouse
- Chicken
- Zebrafish
- Mus musculus
- E.coli
- Wheat Germ
- Mammalian Cell
- HEK293
- HEK293T
- In Vitro Cell Free System
- Mammalian cells
- E.coli expression system
- His
- His&Myc&SUMO
- His&SUMO
- His&T7
- GST
- Non
- His&Fc&Avi
- Myc&DDK
- Flag
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| DCT-11864H | Recombinant Human DCT protein, His-tagged | E.coli | Human | His | 1-350 aa | |
| DCT-2880H | Recombinant Human DCT protein, His-tagged | E.coli | Human | His | 1-350 aa | |
| DCT-1182H | Recombinant Human DCT Protein, His-SUMO/MYC-tagged | E.coli | Human | His&Myc&SUMO | 24-472 a.a. |
|
| DCT-1183M | Recombinant Mouse DCT Protein, His-SUMO-tagged | E.coli | Mouse | His&SUMO | 24-472 a.a. |
|
| DCT-1456H | Recombinant Human DCT protein, His & T7-tagged | E.coli | Human | His&T7 | Val28~Gly263 |
|
| DCT-2406H | Recombinant Human DCT Protein, GST-tagged | Wheat Germ | Human | GST |
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| DCT-4363M | Recombinant Mouse DCT Protein | Mammalian Cell | Mouse | His |
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| DCT-6495C | Recombinant Chicken DCT | Mammalian Cell | Chicken | His |
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| DCT-9099Z | Recombinant Zebrafish DCT | Mammalian Cell | Zebrafish | His |
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| DCT-7045HCL | Recombinant Human DCT 293 Cell Lysate | HEK293 | Human | Non |
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| DCT-1932H | Recombinant Human DCT Protein (Val28-Gly263), N-His tagged | E.coli | Human | His | Val28-Gly263 |
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| DCT-2240M | Recombinant Mouse DCT Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| DCT-2240M-B | Recombinant Mouse DCT Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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| Dct-2479M | Recombinant Mouse Dct Protein, Myc/DDK-tagged | HEK293T | Mouse | Myc&DDK |
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| Dct-2806M | Recombinant Mouse Dct protein, His-SUMO & Myc-tagged | E.coli | Mouse | His&Myc&SUMO | 24-472aa |
|
| DCT-2934HF | Recombinant Full Length Human DCT Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 519 amino acids |
|
| DCT-401HFL | Recombinant Full Length Human DCT Protein, C-Flag-tagged | Mammalian cells | Human | Flag | Full L. |
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| DCT-728H | Recombinant Human DCT Protein, His (Fc)-Avi-tagged | HEK293 | Human | His&Fc&Avi |
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| DCT-728H-B | Recombinant Human DCT Protein Pre-coupled Magnetic Beads | HEK293 | Human |
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| RFL16078MF | Recombinant Full Length Mouse L-Dopachrome Tautomerase(Dct) Protein, His-Tagged | E.coli expression system | Mus musculus | His | Full L. Full Length of Mature Protein (24-517) |
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| RFL18547GF | Recombinant Full Length Chicken L-Dopachrome Tautomerase(Dct) Protein, His-Tagged | E.coli expression system | Chicken | His | Full L. Full Length of Mature Protein (26-521) |
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| RFL32608HF | Recombinant Full Length Human L-Dopachrome Tautomerase(Dct) Protein, His-Tagged | E.coli expression system | Human | His | Full L. Full Length of Mature Protein (24-519) |
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Involved Pathway
DCT involved in several pathways and played different roles in them. We selected most pathways DCT participated on our site, such as Melanin biosynthesis,Melanogenesis,Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with DCT were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Metabolism of amino acids and derivatives | HIBADH,SLC6A12,CDO1,CKMB,NAALAD2,CKMT1B,IVD,OAZ2B,ACMSD,NAGS |
| Melanogenesis | CALML3,PRKACAB,CAMK2D2,MAPK1,KITA,WNT7AA,MAP2K1,CALM1B,CALM1A,PRKACG |
| Tyrosine metabolism | MIF,PNMT,HPD,ADH2-2,AOX2P,FAHD1,AOC2,GSTZ1,MAOB,GOT2 |
| Metabolism | ATP5H,NUDT4,NUDT1,DTYMK,SIN3B,AWAT2,FABP12,BRSK2,SLC25A12,ST3GAL3A |
| Metabolic pathways | ASPA,G6PD,GALNT18,LIPF,NDUFC2,Akr1b3,PDHA2,ACSL3A,PLCZ1,PKMA |
| Neural Crest Differentiation | FOXD3,TCF4,LHX2,TFAP2A,CDH6,PHOX2B,TBX6,CDH7,OLIG1,GBX2 |
Protein Function
DCT has several biochemical functions, for example, copper ion binding,dopachrome isomerase activity,oxidoreductase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by DCT itself. We selected most functions DCT had, and list some proteins which have the same functions with DCT. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| dopachrome isomerase activity | DDT,MIF |
| copper ion binding | MT1,TYRP1,DBH,PRNPA,METTL17,COX11,ATP7A,SERPINB1A,APOA4,F8 |
| oxidoreductase activity | CYP2AA12,AKR1CL1,DHRS13A.1,RDH13,AKR1B7,CYP2AD3,SDR16C5B,SERPINB1A,DHRS7CB,GCDHB |
Interacting Protein
DCT has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DCT here. Most of them are supplied by our site. Hope this information will be useful for your research of DCT.
Resources
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References
- Ueno, M; Aoto, T; et al. Coupling of the radiosensitivity of melanocyte stem cells to their dormancy during the hair cycle. PIGMENT CELL & MELANOMA RESEARCH 27:-(2014).
- Filimon, A; Zurac, SA; et al. Value of dopachrome tautomerase detection in the assessment of melanocytic tumors. MELANOMA RESEARCH 24:219-236(2014).
