DCLK2
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Official Full Name
doublecortin-like kinase 2 -
Overview
This gene encodes a member of the protein kinase superfamily and the doublecortin family. The protein encoded by this gene contains two N-terminal doublecortin domains, which bind microtubules and regulate microtubule polymerization, a C-terminal serine/threonine protein kinase domain, which shows substantial homology to Ca2+/calmodulin-dependent protein kinase, and a serine/proline-rich domain in between the doublecortin and the protein kinase domains, which mediates multiple protein-protein interactions. The microtubule-polymerizing activity of the encoded protein is independent of its protein kinase activity. Mouse studies show that the DCX gene, another family member, and this gene share function in the establishment of hippocampal organization and that their absence results in a severe epileptic phenotype and lethality, as described in human patients with lissencephaly. Multiple alternatively spliced transcript variants have been identified. -
Synonyms
DCLK2;doublecortin-like kinase 2;DCAMKL2, doublecortin and CaM kinase like 2;serine/threonine-protein kinase DCLK2;DCDC3;DCDC3B;DCK2;MGC45428;CaMK-like CREB regulatory kinase 2;CL2;CLICK-II;CLICK2;DCAMK L2;DCAMKL 2;DCDC 3;DCDC 3B;DCK 2;DCLK 2;DCLK2_HUMAN;DKFZp761I032;Doublecortin and CaM kinase like 2;Doublecortin domain-containing protein 3B;Doublecortin like and CAM kinase like 2;Doublecortin like kinase 2;Doublecortin-like and CAM kinase-like 2;Serine/threonine protein kinase DCLK2;OTTHUMP00000220237;OTTHUMP00000220238;OTTHUMP00000220239;OTTHUMP00000220240;doublecortin and CaM kinase-like 2;doublecortin domain-containing;CLIK2;DCAMKL2
Recombinant Proteins
- Rat
- Human
- Mouse
- Zebrafish
- Mammalian Cell
- Insect Cell
- Wheat Germ
- HEK293
- E.coli
- HEK293T
- In Vitro Cell Free System
- His
- GST
- Non
- Myc&DDK
- His&GST
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| DCLK2-1794R | Recombinant Rat DCLK2 Protein | Mammalian Cell | Rat | His |
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| DCLK2-2393H | Active Recombinant Human DCLK2 Protein, GST-tagged | Insect Cell | Human | GST |
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| DCLK2-2394H | Recombinant Human DCLK2 Protein, GST-tagged | Wheat Germ | Human | GST |
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| DCLK2-26989TH | Recombinant Human DCLK2 | Human | Non | 1-690 a.a. |
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| DCLK2-4351M | Recombinant Mouse DCLK2 Protein | Mammalian Cell | Mouse | His |
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| DCLK2-7182Z | Recombinant Zebrafish DCLK2 | Mammalian Cell | Zebrafish | His |
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| DCLK2-7391Z | Recombinant Zebrafish DCLK2 | Mammalian Cell | Zebrafish | His |
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| DCLK2-7392Z | Recombinant Zebrafish DCLK2 | Mammalian Cell | Zebrafish | His |
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| DCLK2-7393Z | Recombinant Zebrafish DCLK2 | Mammalian Cell | Zebrafish | His |
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| DCLK2-1168H | Recombinant Human DCLK2 Protein, MYC/DDK-tagged | HEK293 | Human | Myc&DDK |
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| DCLK2-1318H | Recombinant Human DCLK2 Protein, His&GST-tagged | E.coli | Human | His&GST | Met1-Cys246 |
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| Dclk2-1319M | Recombinant Mouse Dclk2 Protein, His-tagged | E.coli | Mouse | His | Met1-Lys291 |
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| DCLK2-1452R | Recombinant Rat DCLK2 Protein, His (Fc)-Avi-tagged | HEK293 | Rat | His&Fc&Avi |
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| DCLK2-1452R-B | Recombinant Rat DCLK2 Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
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| DCLK2-2232M | Recombinant Mouse DCLK2 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| DCLK2-2232M-B | Recombinant Mouse DCLK2 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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| Dclk2-2474M | Recombinant Mouse Dclk2 Protein, Myc/DDK-tagged | HEK293T | Mouse | Myc&DDK |
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| DCLK2-2880HF | Recombinant Full Length Human DCLK2 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 695 amino acids |
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Involved Pathway
DCLK2 involved in several pathways and played different roles in them. We selected most pathways DCLK2 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with DCLK2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
DCLK2 has several biochemical functions, for example, ATP binding,kinase activity,nucleotide binding. Some of the functions are cooperated with other proteins, some of the functions could acted by DCLK2 itself. We selected most functions DCLK2 had, and list some proteins which have the same functions with DCLK2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATP binding | PRKAG2,CTPS2,ACTR3B,UCK1,DCLK1,TTLL6,FARS2,ATP6V1A,STK32B,BAT1 |
| protein serine/threonine kinase activity | MYO3B,STK38A,VRK1,OXSR1A,TP53RK,TRPM6,NEK2,CSNK1A1,PIM3,MARK3 |
| protein kinase activity | MAPK8B,DYRK1AA,TSSK1,CDK1,PINK1,PRKACBA,TGFBR1,PRKCBA,POMK,RNASEL |
| kinase activity | CAMK2G1,SBK1,FGGY,SGK2A,PLAUA,PRKRIRA,PKLR,PIP5K1AA,CKBA,MAP3K4 |
| transferase activity | ADKA,CHST2,GLT8D1,ZDHHC3B,TNK2B,AGPAT9L,PRDM13,SETDB1B,B3GNT7L,ANKK1 |
| nucleotide binding | MXA,RAB5AA,RBM3,HNRNPC,EEF1A1A,SNRPA,RBM20,RHOGC,RHOBTB2A,ABCG5 |
Interacting Protein
DCLK2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DCLK2 here. Most of them are supplied by our site. Hope this information will be useful for your research of DCLK2.
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