DAZAP2
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Official Full Name
DAZ associated protein 2 -
Overview
This gene encodes a proline-rich protein which interacts with the deleted in azoospermia (DAZ) and the deleted in azoospermia-like gene through the DAZ-like repeats. This protein also interacts with the transforming growth factor-beta signaling molecule SARA (Smad anchor for receptor activation), eukaryotic initiation factor 4G, and an E3 ubiquitinase that regulates its stability in splicing factor containing nuclear speckles. The encoded protein may function in various biological and pathological processes including spermatogenesis, cell signaling and transcription regulation, formation of stress granules during translation arrest, RNA splicing, and pathogenesis of multiple myeloma. Multiple transcript variants encoding different isoforms have been found for this gene. -
Synonyms
DAZAP2;DAZ associated protein 2;DAZ-associated protein 2;KIAA0058;Deleted in azoospermia associated protein 2;MGC14319;MGC766;Proline rich transcript brain expressed protein;Proline rich transcript in brain;PRTB;proline-rich transcript in brain;deleted in azoospermia-associated protein 2;proline-rich transcript, brain-expressed protein
Recombinant Proteins
- Zebrafish
- Rat
- Human
- Mouse
- Cynomolgus
- Mammalian Cell
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- E.coli
- His
- GST
- His&Fc&Avi
Involved Pathway
DAZAP2 involved in several pathways and played different roles in them. We selected most pathways DAZAP2 participated on our site, such as Circadian Exercise,Diurnally regulated genes with circadian orthologs, which may be useful for your reference. Also, other proteins which involved in the same pathway with DAZAP2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Circadian Exercise | CRY3,NR1D2B,QKI2,ZFR,QK,GFRA1B |
| Diurnally regulated genes with circadian orthologs | EIF4G2,ZFR,NR1D2,QK,TOB1,RBPMS,CBX3,G0S2,CEBPB,ERC2 |
Protein Function
DAZAP2 has several biochemical functions, for example, WW domain binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by DAZAP2 itself. We selected most functions DAZAP2 had, and list some proteins which have the same functions with DAZAP2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | MED25,GIMAP5,TIMM10,PGK1,ICA1,SPAT-1,HEBP2,SEPT2,ZNF69,DCTN5 |
| WW domain binding | TNK2,TCEAL2,TMEM128,SHISA5,WBP11,DNM2,TRP63,CDC25C,TP63,LITAF |
Interacting Protein
DAZAP2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DAZAP2 here. Most of them are supplied by our site. Hope this information will be useful for your research of DAZAP2.
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