DAZAP1
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Official Full Name
DAZ associated protein 1 -
Overview
In mammals, the Y chromosome directs the development of the testes and plays an important role in spermatogenesis. A high percentage of infertile men have deletions that map to regions of the Y chromosome. The DAZ (deleted in azoospermia) gene cluster maps to the AZFc region of the Y chromosome and is deleted in many azoospermic and severely oligospermic men. It is thought that the DAZ gene cluster arose from the transposition, amplification, and pruning of the ancestral autosomal gene DAZL also involved in germ cell development and gametogenesis. This gene encodes a RNA-binding protein with two RNP motifs that was originally identified by its interaction with the infertility factors DAZ and DAZL. Two isoforms are encoded by transcript variants of this gene. -
Synonyms
DAZAP1;DAZ associated protein 1;DAZ-associated protein 1;deleted in azoospermia associated protein 1;MGC19907;deleted in azoospermia-associated protein 1
Recombinant Proteins
- Human
- Chicken
- Mouse
- Zebrafish
- Wheat Germ
- Mammalian Cell
- HEK293
- Mammalian cells
- HEK293T
- In Vitro Cell Free System
- GST
- His
- Non
- Flag
- His&Fc&Avi
- Myc&DDK
Involved Pathway
DAZAP1 involved in several pathways and played different roles in them. We selected most pathways DAZAP1 participated on our site, such as mRNA surveillance pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with DAZAP1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| mRNA surveillance pathway | CPSF6,HBS1L,PPP2R5D,PAPOLB,PPP2R2BB,BAT1,CPSF2,NXT2,SRRM1,BCL2L2-PABPN1 |
Protein Function
DAZAP1 has several biochemical functions, for example, RNA binding,RNA stem-loop binding,nucleotide binding. Some of the functions are cooperated with other proteins, some of the functions could acted by DAZAP1 itself. We selected most functions DAZAP1 had, and list some proteins which have the same functions with DAZAP1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| nucleotide binding | NTRK3A,ACTB2,NCL,ATP1A1A.1,SYNCRIP,GNAI2A,EIF3G,CLCN4-2,BMPR1BA,CPEB4 |
| RNA binding | EIF4E2RS1,RPL18A,EIF4G1A,HNRNPU,DROSHA,SRSF3,NIFK,RPF1,SRSF1A,RBM39A |
| poly(A) RNA binding | EIF4G1,SORBS2,SNRPD1,PEF1,GM5506,NUCKS1,PPIL4,MTDH,HMGN2,RAVER1 |
| RNA stem-loop binding | CPEB3,EPRS,DDX3X |
Interacting Protein
DAZAP1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DAZAP1 here. Most of them are supplied by our site. Hope this information will be useful for your research of DAZAP1.
SF1;ssrna_ug
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