DAZ2
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Official Full Name
deleted in azoospermia 2 -
Overview
This gene is a member of the DAZ gene family and is a candidate for the human Y-chromosomal azoospermia factor (AZF). Its expression is restricted to premeiotic germ cells, particularly in spermatogonia. It encodes an RNA-binding protein that is important for spermatogenesis. Four copies of this gene are found on chromosome Y within palindromic duplications; one pair of genes is part of the P2 palindrome and the second pair is part of the P1 palindrome. Each gene contains a 2.4 kb repeat including a 72-bp exon, called the DAZ repeat; the number of DAZ repeats is variable and there are several variations in the sequence of the DAZ repeat. Each copy of the gene also contains a 10.8 kb region that may be amplified; this region includes five exons that encode an RNA recognition motif (RRM) domain. This gene contains one copy of the 10.8 kb repeat. Alternative splicing results in multiple transcript variants encoding different isoforms. -
Synonyms
DAZ2;deleted in azoospermia 2;deleted in azoospermia protein 2;MGC126442;pDP1678;DAZ3;Deleted in azoospermia2;Deleted in azoospermia protein 3
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Involved Pathway
DAZ2 involved in several pathways and played different roles in them. We selected most pathways DAZ2 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with DAZ2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
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Protein Function
DAZ2 has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by DAZ2 itself. We selected most functions DAZ2 had, and list some proteins which have the same functions with DAZ2. You can find most of the proteins on our site.
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Interacting Protein
DAZ2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DAZ2 here. Most of them are supplied by our site. Hope this information will be useful for your research of DAZ2.
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