DAP3
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Official Full Name
death associated protein 3 -
Overview
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that also participates in apoptotic pathways which are initiated by tumor necrosis factor-alpha, Fas ligand, and gamma interferon. This protein potentially binds ATP/GTP and might be a functional partner of the mitoribosomal protein S27. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. Pseudogenes corresponding to this gene are found on chromosomes 1q and 2q. -
Synonyms
DAP3;death associated protein 3;28S ribosomal protein S29, mitochondrial;bMRP 10;DAP 3;DKFZp686G12159;MGC126058;MGC126059;mitochondrial 28S ribosomal protein S29;MRP S29;MRPS29;S29mt;death-associated protein 3;ionizing radiation resistance co
Recombinant Proteins
- Human
- Mouse
- Zebrafish
- E.coli
- Wheat Germ
- Mammalian Cell
- HEK293
- HEK293T
- In Vitro Cell Free System
- GST
- His
- Non
- His&Fc&Avi
- Myc&DDK
Involved Pathway
DAP3 involved in several pathways and played different roles in them. We selected most pathways DAP3 participated on our site, such as Mitochondrial translation,Mitochondrial translation elongation,Mitochondrial translation initiation, which may be useful for your reference. Also, other proteins which involved in the same pathway with DAP3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Mitochondrial translation termination | MRRF,MRPL54,MRPL39,CHCHD1,MRPS36,MRPL41,MRPL3,MRPL46,MRPS30,MRPS23 |
| Organelle biogenesis and maintenance | LZTFL1,IFT27,PKD1,TTC21B,MRPL41,EXOC3,TTC30B,UNC119B,IFT22,KIF17 |
| Mitochondrial translation initiation | MRPL55,MRPS31,PTCD3,MRPS26,MRPL53,MRPS24,MRPL42,MRPL38,MRPL50,MRPS22 |
| Mitochondrial translation | MRPS25,MRPL52,MTIF3,AURKAIP1,MRPS34,MRPS31,MRPL53,MRPS23,MRPS33,MRPS27 |
| Mitochondrial translation elongation | MRPL45,MRPL28,MRPS34,MRPS35,MRPL55,MRPS33,MRPS31,MRPL3,MRPL41,GFM1 |
Protein Function
DAP3 has several biochemical functions, for example, poly(A) RNA binding,protein binding,structural constituent of ribosome. Some of the functions are cooperated with other proteins, some of the functions could acted by DAP3 itself. We selected most functions DAP3 had, and list some proteins which have the same functions with DAP3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | PRPF4B,PTGIS,GTF2I,KRT20,NEK2,SERBP1,RPLP0,PIGK,JAKMIP1,PDGFB |
| structural constituent of ribosome | FAUA,RPL10L,RPL36AL,FAUB,RPL18,RPL35A,SLC25A47A,MRPL46,RPS8,RPL32 |
| poly(A) RNA binding | DDX31,FUBP3,ZFP106,SMNDC1,KIAA1967,NOA1,MECP2,SAMSN1,EIF1B,DUSP14 |
Interacting Protein
DAP3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DAP3 here. Most of them are supplied by our site. Hope this information will be useful for your research of DAP3.
NOA1;YBX1;C1qbp;ICT1;CNBP;NFKB2;IKBKG;MBNL1;ssrna_ug
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