DACT2
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Official Full Name
dapper homolog 2, antagonist of beta-catenin (xenopus) -
Overview
Negatively regulates the Nodal signaling pathway, possibly by promoting the lysosomal degradation of Nodal receptors. -
Synonyms
DACT2;dapper homolog 2, antagonist of beta-catenin (xenopus);Dpr2;Frd2;dapper2;A630024E20;2900084M21Rik;dapper homolog 2;mDpr2;dapper antagonist of catenin 2;dapper, antagonist of beta-catenin, homolog 2
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| DACT2-2323H | Recombinant Human DACT2 Protein, GST-tagged | Wheat Germ | Human | GST |
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| DACT2-4292M | Recombinant Mouse DACT2 Protein | Mammalian Cell | Mouse | His |
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| DACT2-4867Z | Recombinant Zebrafish DACT2 | Mammalian Cell | Zebrafish | His |
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| DACT2-2193M | Recombinant Mouse DACT2 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| DACT2-2193M-B | Recombinant Mouse DACT2 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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| DACT2-2313HF | Recombinant Full Length Human DACT2 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 280 amino acids |
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Involved Pathway
DACT2 involved in several pathways and played different roles in them. We selected most pathways DACT2 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with DACT2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
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Protein Function
DACT2 has several biochemical functions, for example, beta-catenin binding,delta-catenin binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by DACT2 itself. We selected most functions DACT2 had, and list some proteins which have the same functions with DACT2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein kinase C binding | PEA15A,HDAC9,PARD3,SDC4,PKN1,NELL2,HDAC5,C1QBP,TIRAP,AVPR1B |
| beta-catenin binding | LZIC,CDH1,TBL1XR1,PTPRJ,BCL9L,ASH2L,SMAD7,NF2,BCL9,HDAC6 |
| transcription factor binding | CEBPA,HDAC4,FIGLA,PIM1,HES1,DOT1L,HES3,NCOA2,DIP2BA,ZFPM1 |
| protein binding | RUSC1,DDR1,HSPH1,DNPEP,PSAP,STARD3,ELL,HPS6,ZNF436,ARHGAP1 |
| protein kinase A binding | RARA,AKAP12,RPS3,NBEA,DACT3,AKAP4,AKAP12B,MYRIP,DACT1,LRRK2 |
| delta-catenin binding | CDH24,PLEKHA7,PTPRJ,PLEKHA7A,DACT3,DACT1 |
Interacting Protein
DACT2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DACT2 here. Most of them are supplied by our site. Hope this information will be useful for your research of DACT2.
Hdac1;Ctnnd2;Vang;dco;Tcf3;Lef1;Ctnnd1;GSK3A;dsh;Dvl1;Prkcg;Csnk2b;Tcf7;Ctnnb1;Dact3;Tcf4;Dvl2;Dvl3;Tgfbr1
Resources
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References
- Schussel, JL; Kalinke, LP; et al. Expression and epigenetic regulation of DACT1 and DACT2 in oral squamous cell carcinoma. CANCER BIOMARKERS 15:11-17(2015).
- Zhao, ZY; Herman, JG; et al. Methylation of DACT2 Promotes Papillary Thyroid Cancer Metastasis by Activating Wnt Signaling. PLOS ONE 9:-(2014).
