DAB1
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Official Full Name
disabled homolog 1 -
Overview
The laminar organization of multiple neuronal types in the cerebral cortex is required for normal cognitive function.;In mice, the disabled-1 gene plays a central role in brain development, directing the migration of cortical neurons;past previously formed neurons to reach their proper layer. This gene is similar to disabled-1, and the protein;encoded by this gene is thought to be a signal transducer that interacts with protein kinase pathways to regulate;neuronal positioning in the developing brain. Alternatively spliced transcript variants of this gene have been;reported, but their full length nature has not been determined. -
Synonyms
DAB1;disabled homolog 1 (Drosophila);disabled (Drosophila) homolog 1;disabled homolog 1
Recombinant Proteins
- Rat
- Human
- Mouse
- Cynomolgus
- Chicken
- E.coli
- Mammalian Cell
- Wheat Germ
- HEK293
- HEK293T
- In Vitro Cell Free System
- His
- GST
- Non
- His&Fc&Avi
- Myc&DDK
Involved Pathway
DAB1 involved in several pathways and played different roles in them. We selected most pathways DAB1 participated on our site, such as Lissencephaly gene (LIS1) in neuronal migration and development,Reelin signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with DAB1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Reelin signaling pathway | LRPAP1,MAP1B,VLDLR |
| Lissencephaly gene (LIS1) in neuronal migration and development | NUDC,MAP1B,DYNLT1,VLDLR,DCX,KATNA1,NDEL1,LRPAP1 |
Protein Function
DAB1 has several biochemical functions, for example, phosphatidylinositol 3-kinase binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by DAB1 itself. We selected most functions DAB1 had, and list some proteins which have the same functions with DAB1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| phosphatidylinositol 3-kinase binding | IGF1R,LCK,CORO1A,HCST,IGF1RB,PDGFRB,CALM3,FLT3,IRS4,IRS1 |
| protein binding | SETD6,NTF3,ALDH7A1,ATG3,HMMR,PTGDS,TNNT1,SREBF1,USP18,CHRD |
Interacting Protein
DAB1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DAB1 here. Most of them are supplied by our site. Hope this information will be useful for your research of DAB1.
a0a024r5s0_human;ZBTB32;ROR2;ARID5A;SIRPB1
Resources
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References
- Onoue, A; Takeuchi, M; et al. Aberrant fragment of Dab1 protein is present in yotari mouse. NEUROSCIENCE RESEARCH 88:23-27(2014).
- Gaillard, F; Kuny, S; et al. Retinal distribution of Disabled-1 in a diurnal murine rodent, the Nile grass rat Arvicanthis niloticus. EXPERIMENTAL EYE RESEARCH 125:236-243(2014).
