Cyp11b2
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Official Full Name
cytochrome P450, family 11, subfamily b, polypeptide 2
Recombinant Proteins
- Rhesus macaque
- Human
- Mammalian Cell
- E.coli
- HEK293
- Yeast
- His
- His&SUMO
- Non
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| CYP11B2-1134R | Recombinant Rhesus monkey CYP11B2 Protein, His-tagged | Mammalian Cell | Rhesus macaque | His |
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| CYP11B2-1179H | Recombinant Human CYP11B2 Protein, His/SUMO-tagged | E.coli | Human | His&SUMO | 25-503 a.a. |
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| CYP11B2-194H | Recombinant Human CYP11B2 | Mammalian Cell | Human | His |
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| CYP11B2-7129HCL | Recombinant Human CYP11B2 293 Cell Lysate | HEK293 | Human | Non |
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| CYP11B2-2190H | Recombinant Human CYP11B2 Protein (25-503 aa), His-tagged | Yeast | Human | His | 25-503 aa |
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| CYP11B2-2766H | Recombinant Human CYP11B2 Protein, His (Fc)-Avi-tagged | HEK293 | Human | His&Fc&Avi |
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| CYP11B2-2766H-B | Recombinant Human CYP11B2 Protein Pre-coupled Magnetic Beads | HEK293 | Human |
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| CYP11B2-959R | Recombinant Rhesus Macaque CYP11B2 Protein, His (Fc)-Avi-tagged | HEK293 | Rhesus macaque | His&Fc&Avi |
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| CYP11B2-959R-B | Recombinant Rhesus Macaque CYP11B2 Protein Pre-coupled Magnetic Beads | HEK293 | Rhesus macaque |
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Involved Pathway
Cyp11b2 involved in several pathways and played different roles in them. We selected most pathways Cyp11b2 participated on our site, such as ACE Inhibitor Pathway,Aldosterone synthesis and secretion,Biological oxidations, which may be useful for your reference. Also, other proteins which involved in the same pathway with Cyp11b2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Aldosterone synthesis and secretion | KCNK9,CALM1,CALM4,ITPR3,CAMK1D,PRKD1,PRKCB,CREB3L1,CREB3L2,ADCY7 |
| Mineralcorticoid Metabolism | AKR1C21,CYP17A1,CYP21A2 |
| Endogenous sterols | FDXR,POMCB,CYP7A1,CYP27A1,CYP51A1,FDX1,CYP8B2,CYP11B1,CYP11A1,FDX1L |
| Cytochrome P450 - arranged by substrate type | CYP26A1,POMCB,CYP2K22,CYP3A5,CYP3C4,CYP2V1,CYP2F1,CYP27B1,CYP2W1,CYP2S1 |
| Biological oxidations | SLC35D1A,CYP2E1,CYP2Y3,CYP3A5,FDX1,FDX1L,CYP17A1,DPEP1,ACY3.2,CYP8B2 |
| amp | CYP17A1,CYP21A2,AKR1C21 |
| ACE Inhibitor Pathway | AGT,ATP6AP2,AGTR1,CTSG,AGTR2,ACE,CMA1 |
| Glucocorticoid & | CYP17A1,AKR1C21,CYP21A2 |
| Metabolic pathways | GLUL,UGT8A,B3GALT2,TST,PYCR1B,ACOT2,PAFAH1B1A,ADH1C,AGXT2L1,COQ6 |
Protein Function
Cyp11b2 has several biochemical functions, for example, corticosterone 18-monooxygenase activity,heme binding,iron ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Cyp11b2 itself. We selected most functions Cyp11b2 had, and list some proteins which have the same functions with Cyp11b2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| iron ion binding | ALOX5A,CYGB1,P3H2,CYP2H1,CYP2A13,CYP2D26,CYP21A1,BRSK2,LTF,CYP2C38 |
| heme binding | HBAE1,CYP4F3,CYP1D1,CYP2D9,CYP2C39,CYP2C19,CYP3A7,CYB5B,CYP2A6,LPO |
| oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen | NDOR1,CYP4F11,MICAL1,CYP4F18,CYP11A1,MTRR,CYP4F2,MICAL2,CYP2E1,CYP11C1 |
| corticosterone 18-monooxygenase activity | CYP11B1,CYP11C1 |
| steroid 11-beta-monooxygenase activity | CYP11B1,CYP11C1 |
Interacting Protein
Cyp11b2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Cyp11b2 here. Most of them are supplied by our site. Hope this information will be useful for your research of Cyp11b2.
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References
- Kuppusamy, M; Caroccia, B; et al. A Novel KCNJ5-insT149 Somatic Mutation Close to, but Outside, the Selectivity Filter Causes Resistant Hypertension by Loss of Selectivity for Potassium. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM 99:E1765-E1773(2014).
- Nakamura, Y; Maekawa, T; et al. Adrenal CYP11B1/2 expression in primary aldosteronism: Immunohistochemical analysis using novel monoclonal antibodies. MOLECULAR AND CELLULAR ENDOCRINOLOGY 392:73-79(2014).
