Ctsc
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Official Full Name
cathepsin C -
Overview
The protein encoded by this gene, a member of the peptidase C1 family, is a lysosomal cysteine proteinase that appears to be a central coordinator for activation of many serine proteinases in immune/inflammatory cells. It is composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor, and a residual portion of the propeptide acts as an intramolecular chaperone for the folding and stabilization of the mature enzyme. This enzyme requires chloride ions for activity and can degrade glucagon. Defects in the encoded protein have been shown to be a cause of Papillon-Lefevre syndrome, an autosomal recessive disorder characterized by palmoplantar keratosis and periodontitis. Multiple transcript variants encoding different isoforms have been found for this gene. -
Synonyms
CTSC;cathepsin C;PALS, PLS;dipeptidyl peptidase 1;DPP1;AI047818;CATC;Cathepsin J;CPPI;Dipeptidyl transferase;DPP I;DPPI;EC 3.4.14.1;HMS;JP;JPD;MGC126959;PALS;PLS;dipeptidyl peptidase I;dipeptidyl-peptidase I;DPP-I
Recombinant Proteins
- Mouse
- Human
- Rhesus macaque
- Zebrafish
- Rat
- Cynomolgus
- HEK293
- Mammalian cells
- Mammalian Cell
- Wheat Germ
- Human Cell
- E.coli
- In Vitro Cell Free System
- HEK293T
- His
- GST
- Non
- His&Fc&Avi
- Flag
- Myc&DDK
- N-His&C-Myc
Involved Pathway
Ctsc involved in several pathways and played different roles in them. We selected most pathways Ctsc participated on our site, such as Adaptive Immune System,Asparagine N-linked glycosylation,COPII (Coat Protein 2) Mediated Vesicle Transport, which may be useful for your reference. Also, other proteins which involved in the same pathway with Ctsc were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Asparagine N-linked glycosylation | TRAPPC6B,TRAPPC6A,NAPAA,STT3A,ALG10B,USO1,TRAPPC2L,TRAPPC1,LMAN2L,MGAT4A |
| Lysosome | GNSA,GALCB,GALC,GLA,DNASE2A,LAMP2,AP4M1,PLA2G15,MANBA,SUMF1 |
| ER to Golgi Anterograde Transport | CNIH3,TRAPPC6B,SERPINA1L,TFG,TMED2,PREB,CNIH,NAPAB,GOLGA2,MIA3 |
| MHC class II antigen presentation | CTSO,RACGAP1,KIF3B,KIF26A,CTSLL,MGC174152,MGC174857,DYNC1I1,FAM49BA,OSBPL1A |
| COPII (Coat Protein 2) Mediated Vesicle Transport | TFG,TRAPPC2,SEC22C,PPP6R1,SERPINA1L,TRAPPC1,NSFB,NAPB,LMAN2L,TRAPPC6A |
| Adaptive Immune System | MALT1,UBA5,LILRB2,KIF18A,CD300LF,LILRB3,FBXO44,MAP3K8,UBE2F,CD300LH |
| Cargo concentration in the ER | TMED10,LMAN2,CTSZ,SEC24A,CNIH3,CNIH,LMAN2L,SERPINA1L,AREG,MIA3 |
| Immune System | MB21D1,SIGLEC15,TRAF7,CD160,B2ML,GRAP2A,LGALS3,TREML1,RNF19B,CD200 |
Protein Function
Ctsc has several biochemical functions, for example, chaperone binding,chloride ion binding,cysteine-type endopeptidase activator activity involved in apoptotic process. Some of the functions are cooperated with other proteins, some of the functions could acted by Ctsc itself. We selected most functions Ctsc had, and list some proteins which have the same functions with Ctsc. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| identical protein binding | DIAPH1,DESI1,AIM2,SORD,SF1,KCNH2,VIL1,MUL1,CEACAM16,COL1A2 |
| cysteine-type endopeptidase activity | USP17L2,CASP9,CTSB,USP18,CASP6,CASP1,CTSBB,USP37,USP24,CASPA |
| chloride ion binding | AMY2A,Amy1,NLGN4X,SLC22A6,ACE |
| protein binding | PYDC1,PLAC9,RDBP,IPO4,SLC6A18,ATXN1,AUNIP,POU4F1,PEG10,PMM1 |
| cysteine-type endopeptidase activator activity involved in apoptotic process | NOD1,RPS27L,CASP1,CARD8,CTSH,APAF1,BCL2L13,NLRP12,PYCARD,BAD |
| serine-type endopeptidase activity | GZMM,TMPRSS13A,PIK3IP1,PRSS27,PRSS38,PCSK5B,ST14,KLK1B22,KLK1B3,TMPRSS13B |
| phosphatase binding | SLC9A3R2,MAST2,PPP1R32,DYSFIP1,ELFN2,PPP1R27,SLC9A3R1,ELL,TSC2,KIAA0649 |
| cysteine-type peptidase activity | CAPN1A,SENP8,PIGK,SENP3A,SOLH,ATG4B,OTUD4,USP12A,FAM49BA,ATG4A |
| chaperone binding | H2-KE2,PARK2,DNAJB8,CP,CDC37,Alb,FGB,CALR,GNB5,BAX |
Interacting Protein
Ctsc has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Ctsc here. Most of them are supplied by our site. Hope this information will be useful for your research of Ctsc.
CST7;q1hvd6_ebva8;q7cgu7_yerpe;pepS;tal1;nrdB;nemA;gcvP;Bub1;Ktn1;Nek2;FGFR1OP;Tuba3a;MAPK8;Smo;G3BP1;SGOL1;Ppp2r1a
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References
- Wang, XW; Liu, Y; et al. Long-term change of disease behavior in Papillon-Lefevre syndrome: Seven years follow-up. EUROPEAN JOURNAL OF MEDICAL GENETICS 58:184-187(2015).
- Gregersen, VR; Gustavsson, F; et al. Bovine chromosomal regions affecting rheological traits in rennet-induced skim milk gels. JOURNAL OF DAIRY SCIENCE 98:1261-1272(2015).
