Col4a5
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Official Full Name
COL4A5 collagen, type IV, alpha 5 [ Homo sapiens ] -
Overview
This gene encodes one of the six subunits of type IV collagen, the major structural component of basement membranes. Mutations in this gene are associated with X-linked Alport syndrome, also known as hereditary nephritis. Like the other members of the type IV collagen gene family, this gene is organized in a head-to-head conformation with another type IV collagen gene so that each gene pair shares a common promoter. Alternatively spliced transcript variants have been identified for this gene. -
Synonyms
Arresten;Canstatin;CO4A1_HUMAN;COL4A1;COL4A1 NC1 domain;COL4A2;COL4A3;COL4A4;COL4A5;Collagen Alpha 1(IV) Chain;Collagen Alpha 2(IV) Chain;collagen alpha-1(IV) chain;Collagen IV Alpha 1 Polypeptide;Collagen IV Alpha 2 Polypeptide;Collagen Of Basement Membrane Alpha 1 Chain;Collagen Of Basement Membrane Alpha 2 Chain;Collagen Type IV Alpha 1;Collagen Type IV Alpha 2;Collagen Type IV Alpha 3;Collagen Type IV Alpha 4;Collagen Type IV Alpha 5;DKFZp686I14213;FLJ22259
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| COL4A5-11435H | Recombinant Human COL4A5 protein, GST-tagged | E.coli | Human | GST | 423-552 aa | |
| COL4A5-6638Z | Recombinant Zebrafish COL4A5 | Mammalian Cell | Zebrafish | His |
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| COL4A5-2713H | Recombinant Human COL4A5 protein(41-550 aa), C-His-tagged | HEK293 | Human | His | 41-550 aa |
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| COL4A5-332H | Recombinant Human COL4A5 Protein, His-tagged | E.coli | Human | His | Gly1461~Thr1685 |
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Involved Pathway
Col4a5 involved in several pathways and played different roles in them. We selected most pathways Col4a5 participated on our site, such as Amoebiasis,Assembly of collagen fibrils and other multimeric structures,Axon guidance, which may be useful for your reference. Also, other proteins which involved in the same pathway with Col4a5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Extracellular matrix organization | LOX,CRTAP,NID2,COL10A1A,PTPRS,TIMP2,COL13A1,COL5A3A,EMID2,TLL2 |
| Assembly of collagen fibrils and other multimeric structures | CTSB,COL5A3B,COL4A4,CTSS,MMP13,COL6A1,COL10A1A,DST,CTSL1,COL8A1 |
| Amoebiasis | COL24A1,SERPINB3C,SERPINB3,GNAS,LAMB4,ACTN3,PRKCB,SERPINB9,ITGB2,PIK3CB |
| Axon guidance | NFATC3,CDK5R1B,SLIT3,PLXNA1,EFNA1,PAK2,CSNK2B,NTNG1,PPP3R1,TRPC7 |
| Collagen biosynthesis and modifying enzymes | PPIB,BMP1B,COL13A1,COL5A3B,ADAMTS2,COL6A3,COL8A1,PCOLCEB,COL17A1A,LEPRE1 |
| Collagen formation | COL28A1D,COL17A1,COL28A1A,COL19A1,BMP1,PRP,DST,LOXL3,TLL1,COL4A3 |
| Developmental Biology | EFNA5,ARPC3,LGI4,SPAG9,SPRED3,PAQR3B,NR2F2,KALRN,CAP1,GDF1 |
| ECM-receptor interaction | COL27A1,SPP1,FN1,GP9,VTNB,SDC4,COL1A1,ITGA6,THBS3,THBS1 |
Protein Function
Col4a5 has several biochemical functions, for example, extracellular matrix structural constituent. Some of the functions are cooperated with other proteins, some of the functions could acted by Col4a5 itself. We selected most functions Col4a5 had, and list some proteins which have the same functions with Col4a5. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| extracellular matrix structural constituent | MATN1,LAMB1,EFEMP2,COL24A1,COL5A3B,FBN2B,COL4A3,COL5A2,COL1A1A,COL11A1A |
Interacting Protein
Col4a5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Col4a5 here. Most of them are supplied by our site. Hope this information will be useful for your research of Col4a5.
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References
- Hashimura, Y; Nozu, K; et al. Milder clinical aspects of X-linked Alport syndrome in men positive for the collagen IV alpha 5 chain. KIDNEY INTERNATIONAL 85:1208-1213(2014).
- Olaru, F; Luo, WT; et al. Quaternary Epitopes of alpha 345(IV) Collagen Initiate Alport Post-Transplant Anti-GBM Nephritis. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY 24:889-895(2013).
