Ces2c
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Official Full Name
carboxylesterase 2C -
Overview
This gene encodes a member of the carboxylesterase large family. The family members are responsible for the hydrolysis or transesterification of various xenobiotics, such as cocaine and heroin, and endogenous substrates with ester, thioester, or amide bonds. They may participate in fatty acyl and cholesterol ester metabolism, and may play a role in the blood-brain barrier system. The protein encoded by this gene is the major intestinal enzyme and functions in intestine drug clearance. The transcription of this gene is regulated by several factors including HNF-4alpha (hepatocyte nuclear factor-4alpha), Sp1 (specificity protein 1), Sp3 and USF1 (upstream stimulatory factor 1). The expression and activity of this gene is age-related but independent of growth hormone level. This gene is clustered with several family members including a few of pseudogenes and Ces5 on chromosome 8. -
Synonyms
Ces2c;carboxylesterase 2C;Ces2;ces2A3;carboxylesterase 2;carboxylesterase ML3;acylcarnitine hydrolase M1;EC 3.1.1.1
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| Ces2c-911M | Active Recombinant Mouse Ces2c protein, His-tagged | HEK293 | Mouse | His | Met1-Lys557 | |
| CES2C-3330M | Recombinant Mouse CES2C Protein | Mammalian Cell | Mouse | His |
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| CES2-2199MCL | Recombinant Mouse CES2 cell lysate | Human Cell | Mouse | Non |
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| CES2C-1602M | Recombinant Mouse CES2C Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| CES2C-1602M-B | Recombinant Mouse CES2C Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
Ces2c involved in several pathways and played different roles in them. We selected most pathways Ces2c participated on our site, such as Drug metabolism - other enzymes, which may be useful for your reference. Also, other proteins which involved in the same pathway with Ces2c were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Drug metabolism - other enzymes | TYMP,UGT2B15,IMPDH2,GMPS,UGT1A6A,IMPDH1,CES1D,UGT2B7,NAT1,UPP1 |
Protein Function
Ces2c has several biochemical functions, for example, acylcarnitine hydrolase activity,carboxylic ester hydrolase activity,hydrolase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by Ces2c itself. We selected most functions Ces2c had, and list some proteins which have the same functions with Ces2c. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| carboxylic ester hydrolase activity | LIPH,LYPLAL1,ABHD5,CES1C,ACOT2,ACOT12,LYPLA2,ACOT1,ABHD4,CES1 |
| hydrolase activity | GM5077,C6AST4,ATP2B1B,PTPRZ1,CHD8,ATP13A3,PRSS28,HDHD1,RPE65A,TIGARB |
Interacting Protein
Ces2c has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Ces2c here. Most of them are supplied by our site. Hope this information will be useful for your research of Ces2c.
Ywhae;Ywhaz;Hsd3b4;Hsd3b7
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