Cep63

  • Official Full Name

    CEP63 centrosomal protein 63kDa [ Homo sapiens ]

  • Overview

    This gene encodes a protein with six coiled-coil domains. The protein is localized to the centrosome, a non-membraneous organelle that functions as the major microtubule-organizing center in animal cells. Several alternatively spliced transcript variants have been found, but their biological validity has not been determined.

  • Synonyms

    centrosomal protein 63kDa;FLJ13386;centrosomal protein of 63 kDa;centrosome protein CEP63;Cep63

Recombinant Proteins

  • Human
  • Zebrafish
  • Rat
  • Chicken
  • E.coli
  • Mammalian Cell
  • Wheat Germ
  • HEK293
  • In Vitro Cell Free System
  • GST
  • His
  • Non
  • His&Fc&Avi
  • His&SUMO
Cat.# Product name Source (Host) Species Tag Protein Length Price
CEP63-11114H Recombinant Human CEP63, GST-tagged E.coli Human GST 1-349a.a.
CEP63-10880Z Recombinant Zebrafish CEP63 Mammalian Cell Zebrafish His
CEP63-1138H Recombinant Human CEP63 Protein, GST-Tagged Wheat Germ Human GST
CEP63-1345R Recombinant Rat CEP63 Protein Mammalian Cell Rat His
CEP63-4039C Recombinant Chicken CEP63 Mammalian Cell Chicken His
CEP63-7571HCL Recombinant Human CEP63 293 Cell Lysate HEK293 Human Non
CEP63-1003R Recombinant Rat CEP63 Protein, His (Fc)-Avi-tagged HEK293 Rat His&Fc&Avi
CEP63-1003R-B Recombinant Rat CEP63 Protein Pre-coupled Magnetic Beads HEK293 Rat
CEP63-3210H Recombinant Human CEP63 Protein, His-tagged E.coli Human His
CEP63-3238HF Recombinant Full Length Human CEP63 Protein, GST-tagged In Vitro Cell Free System Human GST Full L. 541 amino acids
CEP63-4676H Recombinant Human CEP63 protein, His-SUMO-tagged E.coli Human His&SUMO 1-495aa

    Involved Pathway

    Cep63 involved in several pathways and played different roles in them. We selected most pathways Cep63 participated on our site, such as Anchoring of the basal body to the plasma membrane,Assembly of the primary cilium,Cell Cycle, which may be useful for your reference. Also, other proteins which involved in the same pathway with Cep63 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Anchoring of the basal body to the plasma membrane CEP72,RAB3IP,DYNC1I2,BBS13,NPHP4,TUBB4B,OFD1,DCTN2,CETN2,CEP57
    Centrosome maturation CEP152,CEP290,CCP110,DCTN1,TUBGCP3,CEP135,TUBGCP2,NUMA1,FGFR1OP,CDK11A
    Cell cycle YWHAZ,YWHAG,NUPL2,RBBP7,PTTG1,MYC,LIN54,NCAPG,TFDP1,YWHAG1
    Cell Cycle, Mitotic LMNB1,CEP76,MAPRE1B,MCM10,TUBGCP4,TUBGCP2,NDEL1A,DYNC1I2,NUP50,STAG2
    G2/M Transition CLASP1A,LIN37,ODF2B,CCP110,FOXM1,LIN52,NEDD1,TSGA14,TUBGCP5,TUBG1
    Loss of Nlp from mitotic centrosomes CEP76,CEP70,CKAP5,MAPRE1A,CEP164,PLK4,TSGA14,NDE1,SSNA1,CP110
    Assembly of the primary cilium SDCCAG8,DCTN1A,NINL,MAPRE1B,TTBK2,BBS2,MAPRE1,CYS1,CDK5RAP2,IQCB1
    Loss of proteins required for interphase microtubule organizationfrom the centrosome CEP135,CEP70,NINL,MAPRE1,CEP76,TUBG1,SDCCAG8,CP110,MAPRE1A,SSNA1

    Protein Function

    Cep63 has several biochemical functions, for example, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Cep63 itself. We selected most functions Cep63 had, and list some proteins which have the same functions with Cep63. You can find most of the proteins on our site.

    Function Related Protein
    protein binding GPM6A,DNAJC28,CD81,HIST1H4C,FBXL12,NAA50,BANP,HPS1,DERL3,CD80

    Interacting Protein

    Cep63 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Cep63 here. Most of them are supplied by our site. Hope this information will be useful for your research of Cep63.

    DTNB;TBC1D15;SMARCE1;DISC1;TSHZ3

    Resources

    References

    • Alsara, M; Loffler, H; et al. Cep63 Recruits Cdk1 to the Centrosome-Letter. CANCER RESEARCH 75:777-778(2015).
    • Ma, LN; Quigley, I; et al. Multicilin drives centriole biogenesis via E2f proteins. GENES & DEVELOPMENT 28:1461-1471(2014).

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