CYTH4

  • Official Full Name

    cytohesin 4

  • Overview

    The protein encoded by this gene is a member of the PSCD family. Members of this family have identical structural organization that consists of an N-terminal coiled-coil motif, a central Sec7 domain, and a C-terminal pleckstrin homology (PH) domain. The coiled-coil motif is involved in homodimerization, the Sec7 domain contains guanine-nucleotide exchange protein (GEP) activity, and the PH domain interacts with phospholipids and is responsible for association of PSCDs with membranes. Members of this family appear to mediate the regulation of protein sorting and membrane trafficking. The encoded protein exhibits GEP activity in vitro with both ARF1 and ARF5 but is inactive with ARF6. The structures of this gene and CYTH1 are very similar.

  • Synonyms

    CYTH4;cytohesin 4;pleckstrin homology, Sec7 and coiled coil domains 4 , pleckstrin homology, Sec7 and coiled/coil domains 4 , PSCD4;cytohesin-4;CYT4;AI467541;DJ63G5.1;FLJ00017;PH, SEC7 and coiled coil domain containing protein 4;Pleckstrin homology, SEC7, AND coiled coil domains protein 4;Pscd4;RGD1564842;pleckstrin homology, Sec7 and coiled-coil domains 4;pleckstrin homology, Sec7 and coiled/coil domains 4;PH, SEC7 and coiled-coil domain-containing protein 4

Recombinant Proteins

  • Rhesus macaque
  • Chicken
  • Human
  • Mouse
  • Mammalian Cell
  • E.coli
  • HEK293
  • HEK293T
  • His
  • His&T7
  • Non
  • Myc&DDK
  • His&Fc&Avi
Cat.# Product name Source (Host) Species Tag Protein Length Price
CYTH4-1170R Recombinant Rhesus monkey CYTH4 Protein, His-tagged Mammalian Cell Rhesus macaque His
CYTH4-2043C Recombinant Chicken CYTH4 Mammalian Cell Chicken His
CYTH4-7158H Recombinant Human CYTH4 protein, His & T7-tagged E.coli Human His&T7 Met1~Phe379
CYTH4-7093HCL Recombinant Human CYTH4 293 Cell Lysate HEK293 Human Non
CYTH4-2090H Recombinant Human CYTH4 Protein (Met1-Phe379), N-His tagged E.coli Human His Met1-Phe379
Cyth4-2431M Recombinant Mouse Cyth4 Protein, Myc/DDK-tagged HEK293T Mouse Myc&DDK
CYTH4-4069H Recombinant Human CYTH4 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Human Myc&DDK
CYTH4-995R Recombinant Rhesus Macaque CYTH4 Protein, His (Fc)-Avi-tagged HEK293 Rhesus macaque His&Fc&Avi
CYTH4-995R-B Recombinant Rhesus Macaque CYTH4 Protein Pre-coupled Magnetic Beads HEK293 Rhesus macaque

    Involved Pathway

    CYTH4 involved in several pathways and played different roles in them. We selected most pathways CYTH4 participated on our site, such as Phospholipase D signaling pathway,Endocytosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with CYTH4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Phospholipase D signaling pathway KIT,PPAP2C,PDGFC,MAPK3,PLCB2,LPAR3,AKT2,RALB,TSC1,GNAS
    Endocytosis IL2RG,FOLR2,SNX6,PDGFRA,SH3GLB1B,IQSEC1,ACAP2,IGF1RA,RAB4A,RAB11AL

    Protein Function

    CYTH4 has several biochemical functions, for example, ARF guanyl-nucleotide exchange factor activity,lipid binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CYTH4 itself. We selected most functions CYTH4 had, and list some proteins which have the same functions with CYTH4. You can find most of the proteins on our site.

    Function Related Protein
    lipid binding SEC14L3,BPIFB4,FNBP1,PITPNB,PITPNM3,APOA4,BPIFB6,LPAR4,PACSIN1B,APODA.1
    ARF guanyl-nucleotide exchange factor activity PSD3,CYTH4B,CYTH2,PSD4,CYTH3,IQSEC1,MON2,CYTH1B,FBXO8,GBF1

    Interacting Protein

    CYTH4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CYTH4 here. Most of them are supplied by our site. Hope this information will be useful for your research of CYTH4.

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