CYTH1
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Official Full Name
cytohesin 1 -
Overview
The protein encoded by this gene is a member of the PSCD family. Members of this family have identical structural organization that consists of an N-terminal coiled-coil motif, a central Sec7 domain, and a C-terminal pleckstrin homology (PH) domain. The coiled-coil motif is involved in homodimerization, the Sec7 domain contains guanine-nucleotide exchange protein (GEP) activity, and the PH domain interacts with phospholipids and is responsible for association of PSCDs with membranes. Members of this family appear to mediate the regulation of protein sorting and membrane trafficking. This gene is highly expressed in natural killer and peripheral T cells, and regulates the adhesiveness of integrins at the plasma membrane of lymphocytes. The encoded protein is 83% homologous to that of CYTH2. -
Synonyms
CYTH1;cytohesin 1;pleckstrin homology, Sec7 and coiled coil domains 1 , PSCD1;cytohesin-1;B2 1;D17S811E;cytoadhesin 1;SEC7 homolog B2-1;homolog of secretory protein SEC7;pleckstrin homology, Sec7 and coiled-coil domains 1;PH, SEC7 and coiled-coi
Recombinant Proteins
- Rhesus macaque
- Rat
- Chicken
- Human
- Mouse
- Mammalian Cells
- E.coli
- HEK293
- His
- Non
- His&Fc&Avi
- Flag
- Myc&DDK
Involved Pathway
CYTH1 involved in several pathways and played different roles in them. We selected most pathways CYTH1 participated on our site, such as Phospholipase D signaling pathway,Endocytosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with CYTH1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Phospholipase D signaling pathway | GRM7,PDGFRA,GAB2,PPAP2C,INS2,LPAR2,LPAR5,AGPAT5,SHC2,MAP2K1 |
| Endocytosis | WIPF2B,RAB4A,AP2M1A,RABEP1,CBL,ITCH,EPN1,CHMP1B,PDCD6IP,TFRC |
Protein Function
CYTH1 has several biochemical functions, for example, ARF guanyl-nucleotide exchange factor activity,lipid binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CYTH1 itself. We selected most functions CYTH1 had, and list some proteins which have the same functions with CYTH1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ARF guanyl-nucleotide exchange factor activity | PSD3,CYTH3,CYTH1B,CYTH1A,ARFGEF2,IQSEC1,CYTH4B,MON2,FBXO8,GBF1 |
| lipid binding | APOL1,APOE,FFAR2,CLINT1,AP2A2,VCP,AP2M1B,S100A13,CRABP2B,C3 |
| protein binding | MKRN2,S100A8,LIN7A,FLII,COL10A1,ACAP1,NRG4,STOM,LSM11,HSPA2 |
Interacting Protein
CYTH1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CYTH1 here. Most of them are supplied by our site. Hope this information will be useful for your research of CYTH1.
saicar;ITGB2;PKM;CYTIP;1-phosphatidyl-1d-myo-inositol 3,4,5-trisphosphate
Resources
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References
- El Azreq, MA; Bourgoin, SG; et al. Cytohesin-1 regulates human blood neutrophil adhesion to endothelial cells through beta 2 integrin activation. MOLECULAR IMMUNOLOGY 48:1408-1416(2011).
- Sendide, K; Reiner, NE; et al. Cross-talk between CD14 and complement receptor 3 promotes phagocytosis of mycobacteria: Regulation by phosphatidylinositol 3-kinase and cytohesin-1. JOURNAL OF IMMUNOLOGY 174:4210-4219(2005).
