CYP39A1

  • Official Full Name

    cytochrome P450, family 39, subfamily A, polypeptide 1

  • Overview

    This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum protein is involved in the conversion of cholesterol to bile acids. Its substrates include the oxysterols 25-hydroxycholesterol, 27-hydroxycholesterol and 24-hydroxycholesterol.

  • Synonyms

    CYP39A1;cytochrome P450, family 39, subfamily A, polypeptide 1;cytochrome P450, subfamily XXXIX (oxysterol 7 alpha hydroxylase), polypeptide 1;24-hydroxycholesterol 7-alpha-hydroxylase;hCYP39A1;cytochrome P450 39A1;oxysterol 7alpha-hydroxylase;oxys

Recombinant Proteins

  • Human
  • Rhesus macaque
  • Zebrafish
  • E.coli
  • Mammalian Cell
  • Wheat Germ
  • In Vitro Cell Free System
  • HEK293
  • His
  • GST
  • His&Fc&Avi
Cat.# Product name Source (Host) Species Tag Protein Length Price
CYP39A1-3413H Recombinant Human CYP39A1 protein, His-tagged E.coli Human His 18-274 aa
CYP39A1-1157R Recombinant Rhesus monkey CYP39A1 Protein, His-tagged Mammalian Cell Rhesus macaque His
CYP39A1-2272H Recombinant Human CYP39A1 Protein, GST-tagged Wheat Germ Human GST
CYP39A1-3295Z Recombinant Zebrafish CYP39A1 Mammalian Cell Zebrafish His
CYP39A1-2398HF Recombinant Full Length Human CYP39A1 Protein, GST-tagged In Vitro Cell Free System Human GST Full L. 469 amino acids
CYP39A1-982R Recombinant Rhesus Macaque CYP39A1 Protein, His (Fc)-Avi-tagged HEK293 Rhesus macaque His&Fc&Avi
CYP39A1-982R-B Recombinant Rhesus Macaque CYP39A1 Protein Pre-coupled Magnetic Beads HEK293 Rhesus macaque

    Involved Pathway

    CYP39A1 involved in several pathways and played different roles in them. We selected most pathways CYP39A1 participated on our site, such as Primary bile acid biosynthesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with CYP39A1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Primary bile acid biosynthesis CYP46A1.2,HSD3B7,SCP2A,ACOX2,HSD17B4,CYP46A1.4,CYP46A1.3,CH25HL2,SCP2,AKR1D1

    Protein Function

    CYP39A1 has several biochemical functions, for example, heme binding,iron ion binding,metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CYP39A1 itself. We selected most functions CYP39A1 had, and list some proteins which have the same functions with CYP39A1. You can find most of the proteins on our site.

    Function Related Protein
    monooxygenase activity CYP3A7,CYP2D26,CYP2P9,CYP1B1,BCO1,CYP2C18,CYP2K16,FMO1,YWHAQA,CYP2AA2
    metal ion binding TRIM35-30,TKT,NEK11,FBXO30B,CYP2P7,ZNF334,ZNF713,CACNA1H,ECEL1,SP6
    iron ion binding Scd1,CYP2AA6,CYP4F2,CYP1A1,CYP1C1,PLOD1A,CYP2K18,CH25HL2,CYP2F2,OGFOD2
    oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen PLOD1A,CYP11C1,CYP2AA7,CYP2P8,CYP46A1.3,CYP2A12,CYP2X10.2,CYP19A1B,CYP2K16,CYP4V8
    heme binding CYP2S1,PTGS2,CYP2C39,SDHDB,CYP4A11,CYP2AA6,HBA1,CYP4V8,CYP11B1,CYP27A1

    Interacting Protein

    CYP39A1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CYP39A1 here. Most of them are supplied by our site. Hope this information will be useful for your research of CYP39A1.

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