CYP2A7

  • Official Full Name

    cytochrome P450, family 2, subfamily A, polypeptide 7

  • Overview

    This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum; its substrate has not yet been determined. This gene, which produces two transcript variants, is part of a large cluster of cytochrome P450 genes from the CYP2A, CYP2B and CYP2F subfamilies on chromosome 19q.

  • Synonyms

    CYP2A7;cytochrome P450, family 2, subfamily A, polypeptide 7;cytochrome P450, subfamily IIA (phenobarbital inducible), polypeptide 7;cytochrome P450 2A7;CYP2A;CP2A7_HUMAN;CPA7;CPAD;CYP2A 7;CYPIIA7;Cytochrome P450 IIA4;P450 IIA4;cytochrome P450, subfamily IIA (phenobarbital-inducible), polypeptide 7;P450-IIA4
Cat.# Product name Source (Host) Species Tag Protein Length Price
CYP2A7-2259H Recombinant Human CYP2A7 Protein, GST-tagged Wheat Germ Human GST
CYP2A7-7115HCL Recombinant Human CYP2A7 293 Cell Lysate HEK293 Human Non
CYP2A7-7116HCL Recombinant Human CYP2A7 293 Cell Lysate HEK293 Human Non
CYP2A7-2365HF Recombinant Full Length Human CYP2A7 Protein, GST-tagged In Vitro Cell Free System Human GST Full L. 494 amino acids
CYP2A7-2392H Recombinant Human CYP2A7 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293 Human Myc&DDK

    Involved Pathway

    CYP2A7 involved in several pathways and played different roles in them. We selected most pathways CYP2A7 participated on our site, such as Biological oxidations,CYP2E1 reactions,Cytochrome P450 - arranged by substrate type, which may be useful for your reference. Also, other proteins which involved in the same pathway with CYP2A7 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Metabolism ZDHHC21,ELOVL1A,SLC35B3,THEM5,APOA4B.1,ATP5L,UGT1B1,TPMT.2,PYGMB,ARSI
    Fatty acids CYP4T8,CYP2V1,CYP2AD2,CYP4F22,CYP4A11,CYP2AD3,CYP2B6,CYP2D6,CYP2F1,CYP2AD6
    CYP2E1 reactions CYP2A6,CYP2D6,CYP2C9,CYP2C19,CYP2S1,CYP2E1,CYP2A13,CYP2B6,CYP2Y3,CYP2C8
    Cytochrome P450 - arranged by substrate type CYP2W1,CYP2V1,CYP11B1,CYP4F12,CYP2K16,CYP11A1,CYP3A7-CYP3AP1,CYP2R1,CYP21A2,CYP2K17
    cytochrome P450 POR,CYP4Z1,CYP4F12,CYP20A1,CYB5B,CYP2W1,CYB5R3,CYP4V2,CYB5A
    Biological oxidations CYP3A7-CYP3AP1,ACY3,CYP7A1,AS3MT,ADH8A,CYP1B1,SLC26A2,ADH7,CYP3A4,CYP4F12
    Xenobiotics CYP3C4,CYP3C1,CYP2W1
    Phase 1 - Functionalization of compounds CYP2R1,CYP2F1,CYP2AD3,CYP2K8,CYP2W1,CYP4F12,AADAC,CYP4T8,CYP2C18,CYP2S1

    Protein Function

    CYP2A7 has several biochemical functions, for example, arachidonic acid epoxygenase activity,aromatase activity,heme binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CYP2A7 itself. We selected most functions CYP2A7 had, and list some proteins which have the same functions with CYP2A7. You can find most of the proteins on our site.

    Function Related Protein
    heme binding CYP2AA1,CBS,CYP2C50,CYGB2,CYP2A12,HRG,CYP46A1.2,XGB,CYP2R1,HBAA
    arachidonic acid epoxygenase activity CYP4A11,CYP2AA8,CYP2A6,CYP2C38,CYP2C8,CYP2A12,CYP2A13,CYP2C70,CYP4F2,CYP2C19
    iron ion binding CYP2P6,TPH1A,CYP46A1,CYP2A13,P4HA2,CYP21A1,ALOX12E,CYP2X10.2,CYP3A7,ETHE1
    steroid hydroxylase activity CYP2P10,CYP2J6,CYP2J2,CYP2C55,CYP2A13,CYP2C54,CYP2P9,CYP2AA12,CYP2AA3,CYP2K17
    oxygen binding CYP2V1,CYP2C54,CYP2AA3,CYP2A4,CYP2C8,MB,CYP2E1,CYP26A1,CYP4B1,CYP2AD3
    aromatase activity CYP2C9,CYP3A7,CYP1A1,CYP2D6,CYP2C39,CYP1A,CYP2F1,CYP2C54,CYP4X1,CYP3A4
    oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP2J6,CYP2K18,CYP2C50,CYP2K6,CYP2J5,CYP2X8,CYP2P7,CYP2A4,CYP2F1,CYP2D9

    Interacting Protein

    CYP2A7 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CYP2A7 here. Most of them are supplied by our site. Hope this information will be useful for your research of CYP2A7.

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