CUL3
-
Official Full Name
cullin 3 -
Overview
CUL3 is a component of a ubiquitin E3 ligase that is essential for mitotic division. -
Synonyms
CUL3;cullin 3;cullin-3;CUL-3;OTTHUMP00000164219;OTTHUMP00000203839;OTTHUMP00000203840
Recombinant Proteins
- Human
- Rhesus macaque
- Mouse
- Insect Cell
- Mammalian Cell
- HEK293
- Wheat Germ
- E.coli
- HEK293T
- Mamanlian cells
- In Vitro Cell Free System
- Non
- His
- Myc&DDK
- GST
- Flag
- His&Fc&Avi
Involved Pathway
CUL3 involved in several pathways and played different roles in them. We selected most pathways CUL3 participated on our site, such as Ubiquitin mediated proteolysis, which may be useful for your reference. Also, other proteins which involved in the same pathway with CUL3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Ubiquitin mediated proteolysis | ANAPC5,KLHL9,UBE2J1,UBE2L3A,SYVN1,MGRN1,RCHY1,FZR1A,UBE1Y1,KEAP1 |
Protein Function
CUL3 has several biochemical functions, for example, POZ domain binding,cyclin binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CUL3 itself. We selected most functions CUL3 had, and list some proteins which have the same functions with CUL3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| contributes_to ubiquitin protein ligase activity | CUL2,MED11,SKP2,CUL1,CUL5,CUL1B,FBXL3,FBXL6,MED12,FBXL4 |
| protein binding | HIST1H3D,CYBB,DHRS1,AMOTL2,STAG1,NXT1,LLGL2,SMYD2,Mill2,DUSP7 |
| POZ domain binding | KLHL17,Trl |
| protein heterodimerization activity | HER5,TAS1R3,VEGFA,GABPB1,CHRNA3,TLR1,UGT1A6,NOTCH4,ODZ4,SPTAN1 |
| ubiquitin protein ligase binding | SPOP,TUBA1B,DNM1L,HIF1A,DLG3,OTUB1,SMAD3,FOXO1,Fzd4,TRAF1 |
| protein homodimerization activity | PRPS1,TYW5,THRA,BAK1,KIAA1804,MUC13,MYOM1,EIF2AK1,S100B,PLDN |
| cyclin binding | CDK12,CDKN1A,PFTK1,USP2,CDK2,PTCH1,CDK4,CDK6,CDK13,CDK14 |
| contributes_to ubiquitin-protein transferase activity | KLHL30,FBXL3,KLHDC8A,DTL,KBTBD3,BACH2,KLHL24A,KEAP1A,KLHL14,KLHL24B |
Interacting Protein
CUL3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CUL3 here. Most of them are supplied by our site. Hope this information will be useful for your research of CUL3.
CASP8;SPOP;KLHL2;TNFAIP1;KLHL12;FLJ13057
Resources
Related Services
Related Products
References
- Zuhlke, KA; Johnson, AM; et al. Identification of a Novel Germline SPOP Mutation in a Family With Hereditary Prostate Cancer. PROSTATE 74:983-990(2014).
- Bitar, MS; Liu, CL; et al. Decline in DJ-1 and Decreased Nuclear Translocation of Nrf2 in Fuchs Endothelial Corneal Dystrophy. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE 53:5806-5813(2012).
