CTSF
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Official Full Name
cathepsin F -
Overview
Cathepsins are papain family cysteine proteinases that represent a major component of the lysosomal proteolytic system. Cathepsins generally contain a signal sequence, followed by a propeptide and then a catalytically active mature region. The very long (251 amino acid residues) proregion of the cathepsin F precursor contains a C-terminal domain similar to the pro-segment of cathepsin L-like enzymes, a 50-residue flexible linker peptide, and an N-terminal domain predicted to adopt a cystatin-like fold. The cathepsin F proregion is unique within the papain family cysteine proteases in that it contains this additional N-terminal segment predicted to share structural similarities with cysteine protease inhibitors of the cystatin superfamily. This cystatin-like domain contains some of the elements known to be important for inhibitory activity. CTSF encodes a predicted protein of 484 amino acids which contains a 19 residue signal peptide. Cathepsin F contains five potential N-glycosylation sites, and it may be targeted to the endosomal/lysosomal compartment via the mannose 6-phosphate receptor pathway. The cathepsin F gene is ubiquitously expressed, and it maps to chromosome 11q13, close to the gene encoding cathepsin W. -
Synonyms
CTSF;cathepsin F;CATSF;AI481912;CathepsinF;EC 3.4.22.41
Recombinant Proteins
- Human
- Mouse
- Zebrafish
- E.coli
- Wheat Germ
- Mammalian Cell
- Free Style 293-F Cell
- Insect cell
- HEK293
- In Vitro Cell Free System
- His
- GST
- His&T7
- Non
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| CTSF-2857H | Recombinant Human CTSF protein, His-tagged | E.coli | Human | His | 136 - 484 aa | |
| CTSF-15903H | Recombinant Human CTSF, His-tagged | E.coli | Human | His | 271-484aa |
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| CTSF-2105H | Recombinant Human CTSF Protein, GST-tagged | Wheat Germ | Human | GST |
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| CTSF-4051M | Recombinant Mouse CTSF Protein | Mammalian Cell | Mouse | His |
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| CTSF-4778Z | Recombinant Zebrafish CTSF | Mammalian Cell | Zebrafish | His |
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| CTSF-506H | Recombinant Human Cathepsin F, His-tagged | Free Style 293-F Cell | Human | His | 1-16;20-end a.a. |
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| Ctsf-8182M | Recombinant Mouse Ctsf protein, His & T7-tagged | E.coli | Mouse | His&T7 | Ala249~Asn462 |
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| CTSF-420HCL | Recombinant Human CTSF cell lysate | Human | Non |
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| CTSF-05H | Active Recombinant Human CTSF Protein, His-tagged | Insect cell | Human | His | 20-484aa |
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| CTSF-2066M | Recombinant Mouse CTSF Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| CTSF-2066M-B | Recombinant Mouse CTSF Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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| CTSF-2347HF | Recombinant Full Length Human CTSF Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 484 amino acids |
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| CTSF-5295H | Recombinant Human CTSF protein, His-tagged | E.coli | Human | His | 273-484aa |
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Involved Pathway
CTSF involved in several pathways and played different roles in them. We selected most pathways CTSF participated on our site, such as Lysosome, which may be useful for your reference. Also, other proteins which involved in the same pathway with CTSF were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Lysosome | LAPTM5,GLA,AP1S3B,AP1G2,PPT2,CD68,AP3M1,PSAP,ATP6V0A1B,AP3D1 |
Protein Function
CTSF has several biochemical functions, for example, cysteine-type endopeptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CTSF itself. We selected most functions CTSF had, and list some proteins which have the same functions with CTSF. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| cysteine-type endopeptidase activity | CASP8L1,USP25,USP2,CTSS,CTSBB,ATG4B,USP17L2,USP45,USP50,CTSH |
Interacting Protein
CTSF has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CTSF here. Most of them are supplied by our site. Hope this information will be useful for your research of CTSF.
Resources
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References
- Ahn, CS; Na, BK; et al. Expression characteristics and specific antibody reactivity of diverse cathepsin F members of Paragonimus westermani. PARASITOLOGY INTERNATIONAL 64:37-42(2015).
- Wongwairot, S; Kueakhai, P; et al. Monoclonal antibody against recombinant Fasciola gigantica cathepsin L1H could detect juvenile and adult cathepsin Ls of Fasciola gigantica. PARASITOLOGY RESEARCH 114:133-140(2015).
