CTNNA2
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Official Full Name
catenin (cadherin-associated protein), alpha 2 -
Overview
May function as a linker between cadherin adhesion receptors and the cytoskeleton to regulate cell-cell adhesion and differentiation in the nervous system. Regulates morphological plasticity of synapses and cerebellar and hippocampal lamination during development. Functions in the control of startle modulation. -
Synonyms
CTNNA2;catenin (cadherin-associated protein), alpha 2;catenin alpha-2;cadherin associated protein;related;cancer/testis antigen 114;CAP R;CT114;Alpha catenin related protein;Alpha N Catenin;Cadherin Associated Protein Related;CAPR;Catenin (cadherin associated protein) alpha 2;Catenin alpha 2;CTNN A2;CTNR;DKFZp686H02198;alpha N-catenin;alpha-N-catenin;OTTHUMP00000216460;OTTHUMP00000216461;OTTHUMP00000216462;alpha-catenin-related protein;cadherin-associated protein, related;CAP-R
Recombinant Proteins
- Human
- Rhesus macaque
- Mouse
- Chicken
- Zebrafish
- E.coli
- Mammalian Cell
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- HEK293T
- GST
- His
- Non
- His&Fc&Avi
- Myc&DDK
Involved Pathway
CTNNA2 involved in several pathways and played different roles in them. We selected most pathways CTNNA2 participated on our site, such as Adherens junction,Arrhythmogenic right ventricular cardiomyopathy,Arrhythmogenic right ventricular cardiomyopathy (ARVC), which may be useful for your reference. Also, other proteins which involved in the same pathway with CTNNA2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Endometrial cancer | FOXO3,PIK3CD,SOS1,AKT1,CCND1,GRB2,MAP2K2,ERBB2,MAPK1,AXIN1 |
| Hippo signaling pathway | YWHAZ,FZD5,PPP2R1B,WNT2B,WNT16,YWHAE,PPP2R2C,AREG,PPP2CA,BMP8A |
| Adherens junction | RAC3A,NLK1,CDC42L,LMO7,SSX2IPA,CSNK2B,PTBP3,WASLB,TGFBR1,WAS |
| Arrhythmogenic right ventricular cardiomyopathy | DMD,CDH2,DSP,DES,JUP,CTNNA1,CACNG3,DSC2,CACNG2,DSG2 |
| Arrhythmogenic right ventricular cardiomyopathy (ARVC) | DAG1,DSG2,CDH2,ITGB4,CACNG7,ATP2A2,CACNB1,CACNG6,TCF7,ITGA4 |
| Bacterial invasion of epithelial cells | SEPT1,CTTN,ARPC4,PTK2,ELMO2,WASF1,CD2AP,DNM3,CRK,SEPT3 |
| CDO in myogenesis | TCF3B,BOC,TCF3A,MYOD1,TCF4,CDH2,MEF2AA,MEF2B,CDH4,BNIP2 |
| Developmental Biology | RHOC,MED6,AP2B1,SCN2A,MYOD1,FOXH1,CHL1,RHOB,SEMA3AB,ADAM22 |
Protein Function
CTNNA2 has several biochemical functions, for example, actin filament binding,cadherin binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CTNNA2 itself. We selected most functions CTNNA2 had, and list some proteins which have the same functions with CTNNA2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| structural constituent of cytoskeleton | KRT16,VIM,TLN1,TUBE1,DMD,TUBA8L,ARPC5,CYLC1,SPTA1,TUBGCP2 |
| cadherin binding | TBC1D2,AKAP5,TRPC4,CTNNAL1,CTNNA3,CDH13,PTPRM,OLFM4,CTNNB1,CTNNA1 |
| actin filament binding | MYH11A,CTNNA1,SHROOM2,PKNOX2,SVILA,SYNE3,MYO6,CORO2A,ADSSL1,FSCN2B |
| protein binding | SLC6A18,BAAT,RAB17,GABPB2,KLF4,TINAGL1,FAM164A,FRK,BAP1,MPG |
Interacting Protein
CTNNA2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CTNNA2 here. Most of them are supplied by our site. Hope this information will be useful for your research of CTNNA2.
JUP;EGFR;YAP1;ESR2
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